Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism.
Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism.
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组胺通过直接的 H-1 受体介导机制刺激脑磷脂周转。
DOI：
10.1016/0024-3205(80)90225-8
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发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
Slotkin,TA
中科院分区：
文献类型：
--
作者：
Subramanian,N;Whitmore,WL;Seidler,FJ;Slotkin,TA
组胺内给药使33pi加入脑磷脂呈剂量依赖性增加。这种效果不能被化合物48/80所模仿，这表明缺乏非神经元组胺的参与。这种刺激并没有因为事先用利血平消耗儿茶酚胺而减弱，这表明组胺对磷脂转化的影响是通过直接的组胺能机制介导的。特异性组胺激动剂和拮抗剂的研究表明，H-1受体似乎参与其中。将33pi掺入磷脂可能是评估H-1受体介导的细胞效应的一种有价值的工具。
Intracisternal administration of histamine produced a dose-dependent increase of incorporation of33Pi into brain phospholipids. The effect could not be mimicked by administration of compound 48/80, indicating lack of involvement of non-neuronal histamine. The stimulation was not attenuated by prior depletion of catecholamines with reserpine, indicating that the effect of histamine on phospholipid turnover was mediated by direct histaminergic mechanisms. An H-1 receptor appeared to be involved, as demonstrated by studies with specific histaminergic agonists and antagonists. Incorporation of33Pi into phospholipids may be a valuable tool in evaluating cellular effects mediated through H-1 receptors.