The relative phases of basal ganglia activities dynamically shape effective connectivity in Parkinson's disease.
The relative phases of basal ganglia activities dynamically shape effective connectivity in Parkinson's disease.
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DOI：
10.1093/brain/awv093
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Brown P
中科院分区：
文献类型：
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作者：
Cagnan H;Duff EP;Brown P
振荡电路之间的相位对齐被认为可以优化信息流，但电机电路内的过度同步可能会损害网络功能。Cagnan等人 描述强调过度同步及其终止的过程，以及左旋多巴对其的调节，然后建议可能防止病理性回路相互作用的干预措施。振荡电路之间的相位对齐被认为可以优化信息流，但电机电路内的过度同步可能会损害网络功能。Cagnan等人 描述强调过度同步及其终止的过程，以及左旋多巴对其的调节，然后建议可能防止病理性回路相互作用的干预措施。假设振荡神经回路之间的最佳相位对准可以优化信息流并提高系统性能。这种理论被称为通过连贯性进行沟通。帕金森病患者的基底神经节运动回路表现出夸张的振荡和连贯的活动模式。这种活动模式与运动迟缓、僵硬和震颤等运动系统性能受损有关，这表明一旦运动回路中的净同步超过一定水平，网络功能实际上可能会恶化。在这里，我们的特点强调过度同步和终止的过程。为此，我们分析了5例帕金森病患者（4男1女，年龄37-64岁）的丘脑底核和苍白球的局部场电位记录。我们观察到，丘脑底核和苍白球之间的某些相位对齐放大了β频段的局部神经同步，而其他人要么抑制它，要么没有引起任何显着的变化，相对于代理人。局部β同步的增加与两个原子核锁定在β放大相位对准的时间长短直接相关。至关重要的是，多巴胺前体药物左旋多巴的给药减少了丘脑底和苍白球群体锁相至β放大排列的频率和持续时间。相反，多巴胺，总的持续时间，丘脑底核和苍白球人口对齐的阶段，左β振幅不变的替代品增加。因此，多巴胺能输入电路动态从持续锁定期放大相位对齐，与受损的运动功能，更动态的相位对齐和改善运动功能。多巴胺对局部电路共振的这种影响表明，新的电干预可能会阻止共振相关的病理性电路相互作用。
Phase alignment between oscillatory circuits is thought to optimize information flow, but excessive synchrony within the motor circuit may impair network function. Cagnan et al. characterize the processes that underscore excessive synchronization and its termination, as well as their modulation by levodopa, before suggesting interventions that might prevent pathological circuit interactions. Phase alignment between oscillatory circuits is thought to optimize information flow, but excessive synchrony within the motor circuit may impair network function. Cagnan et al. characterize the processes that underscore excessive synchronization and its termination, as well as their modulation by levodopa, before suggesting interventions that might prevent pathological circuit interactions. Optimal phase alignment between oscillatory neural circuits is hypothesized to optimize information flow and enhance system performance. This theory is known as communication-through-coherence. The basal ganglia motor circuit exhibits exaggerated oscillatory and coherent activity patterns in Parkinson's disease. Such activity patterns are linked to compromised motor system performance as evinced by bradykinesia, rigidity and tremor, suggesting that network function might actually deteriorate once a certain level of net synchrony is exceeded in the motor circuit. Here, we characterize the processes underscoring excessive synchronization and its termination. To this end, we analysed local field potential recordings from the subthalamic nucleus and globus pallidus of five patients with Parkinson's disease (four male and one female, aged 37–64 years). We observed that certain phase alignments between subthalamic nucleus and globus pallidus amplified local neural synchrony in the beta frequency band while others either suppressed it or did not induce any significant change with respect to surrogates. The increase in local beta synchrony directly correlated with how long the two nuclei locked to beta-amplifying phase alignments. Crucially, administration of the dopamine prodrug, levodopa, reduced the frequency and duration of periods during which subthalamic and pallidal populations were phase-locked to beta-amplifying alignments. Conversely ON dopamine, the total duration over which subthalamic and pallidal populations were aligned to phases that left beta-amplitude unchanged with respect to surrogates increased. Thus dopaminergic input shifted circuit dynamics from persistent periods of locking to amplifying phase alignments, associated with compromised motoric function, to more dynamic phase alignment and improved motoric function. This effect of dopamine on local circuit resonance suggests means by which novel electrical interventions might prevent resonance-related pathological circuit interactions.