In vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering
In vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering
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DOI：
10.1016/j.biomaterials.2004.01.038
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发表时间：
2004-12-01
期刊：
影响因子：
14
通讯作者：
Ding, JD
中科院分区：
文献类型：
--
作者：
Wu, LB;Ding, JD
本文系统研究了三种不同配方的无定形聚（D，L-丙交酯-共-乙交酯）三维组织工程多孔支架在37 ℃磷酸盐缓冲溶液中26周的体外降解行为。作为降解时间的函数，测量支架的以下性质：尺寸、重量、抗压强度和模量、聚合物分子量及其分布和孔形态。特别感兴趣的是在潮湿环境中的机械性能的测定。还检测了PBS培养基的pH。根据多孔支架各种性能的变化特征，初步认为其降解过程大致可分为三个阶段。称为准稳定阶段、强度下降阶段、失重阶段和骨架破坏阶段。(C)2004爱思唯尔有限公司保留所有权利。
In vitro degradation behaviours of three-dimensional tissue engineering porous scaffolds made from amorphous poly(D,L-lactide-co-glycolide) with three different formulations have been systematically investigated up to 26 weeks in phosphate buffer saline solution at 37degreesC. The following properties of the scaffolds were measured as a function of degradation time: dimensions, weight, compressive strength and modulus, polymer molecular weight and its distribution, and pore morphology. Of special interest was the determination of mechanical properties in wet environment. The pH of the PBS media was also detected. According to the characteristic changes of the various properties of porous scaffolds, the degradation process is suggested to be roughly divided into three stages tentatively. named as quasi-stable stage, decrease-of-strength stage, loss-of-weight and disruption-of-scaffold stage. (C) 2004 Elsevier Ltd. All rights reserved.