Prevalence and correlates of the metabolic syndrome in a population-based sample of European youth
Prevalence and correlates of the metabolic syndrome in a population-based sample of European youth
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DOI：
10.3945/ajcn.2008.26649
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发表时间：
2009-01-01
影响因子：
7.1
通讯作者：
Brage, Soren
中科院分区：
文献类型：
--
作者：
Ekelund, Ulf;Anderssen, Sigmund;Brage, Soren
背景：青年代谢综合征（MetS）至今尚无统一的定义。因此，代谢综合征的患病率及其与潜在correlates的关联在很大程度上是unknow.Objective：我们的目标是量化的患病率，确定的相关性，并检查与MetS.Design潜在的相关性之间的独立关联：一个基于人群的队列研究进行了10-和15岁的青少年从爱沙尼亚，丹麦，葡萄牙（n = 3193）。MetS根据国际糖尿病联盟定义。相关因素包括母亲的社会经济地位、体重指数（BMI）、高血压、糖尿病患病率、母亲报告的婴儿出生体重和母乳喂养时间。性成熟的数据，客观测量的身体活动，心肺功能，自我报告的体育参与，看电视，和定期玩收集的children.Results：代谢综合征的患病率分别为0.2%和1.4%，在10岁和15岁的孩子，分别。心肺适能（标准化比值比：0.33; 95% CI：0.15，0.75），体力活动（标准化比值比：0.40; 95% CI：0.18，0.88），和母亲BMI（标准化比值比：1.61; 95% CI：1.11，2.34）在调整性别、年龄组、研究地点、出生体重和性成熟后均与代谢综合征独立相关。每天增加10-20%的中等强度的体力活动与被归类为MetS.Conclusions的风险降低了33%：产妇高BMI和低水平的心肺功能和体力活动独立有助于代谢综合征，并可能成为未来干预的目标。相对较小的体力活动增加可能会显着降低健康儿童MetS的风险。美国临床营养杂志2009; 89：90-6.
Background: Until recently, there has been no unified definition of the metabolic syndrome (MetS) in the youth. Therefore, the prevalence of MetS and its association with potential correlates are largely unknown.Objective: The objective was to quantify the prevalence, identify the correlates, and examine the independent associations between potential correlates with MetS.Design: A population-based cohort study was conducted in 10- and 15-y-old youth from Estonia, Denmark, and Portugal (n = 3193). MetS was defined according to the International Diabetes Federation. Correlates included maternal socioeconomic status, body mass index (BMI), hypertension, and prevalent diabetes and maternally reported child's birth weight and duration of breastfeeding. Data on sexual maturity, objectively measured physical activity, cardiorespiratory fitness, self-reported sports participation, television viewing, and regular play were collected for the children.Results: The prevalence of MetS was 0.2% and 1.4% in 10- and 15-y-olds, respectively. Cardiorespiratory fitness (standardized odds ratio: 0.33; 95% CI: 0.15, 0.75), physical activity (standardized odds ratio: 0.40; 95% CI: 0.18, 0.88), and maternal BMI (standardized odds ratio: 1.61; 95% CI: 1.11, 2.34) were all independently associated with MetS after adjustment for sex, age group, study location, birth weight, and sexual maturity. An increase in daily moderate-intensity physical activity by 10-20% was associated with a 33% lower risk of being categorized with MetS.Conclusions: High maternal BMI and low levels of cardiorespiratory fitness and physical activity independently contribute to the MetS and may be targets for future interventions. Relatively small increases in physical activity may significantly reduce the risk of MetS in healthy children. Am J Clin Nutr 2009; 89: 90-6.