ECG conduction disturbances and ryanodine receptor expression levels in occupational lead exposure workers
ECG conduction disturbances and ryanodine receptor expression levels in occupational lead exposure workers
复制标题
职业铅暴露工人的心电图传导障碍和兰尼碱受体表达水平
DOI：
10.1136/oemed-2018-105463
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发表时间：
2019-01
影响因子：
4.9
通讯作者：
Guangqin Fan
中科院分区：
文献类型：
--
作者：
Jie Xie;Guihua Du;Yuanyuan Zhang;Fankun Zhou;Junfang Wu;Huan Jiao;Yanshu Li;Ying Chen;Lu Ouyang;D;an Bo;Chang Feng;Wei Yang;Guangqin Fan
目的大量研究表明，职业性铅暴露可增加心血管疾病的危险性。然而，有关铅对心脏传导系统的潜在影响的证据是稀疏和不确定的。此外，RyR引起的心肌兴奋收缩偶联功能障碍被认为是心血管疾病的发病机制之一。因此，我们研究了职业铅暴露与心电图传导异常之间的关系，以及铅诱导的心电图异常中的RyR。方法对529名铅冶炼工人进行血铅（BPb）、锌原卟啉（ZPP）、心电图及RyR表达水平的检测。根据作业工人血铅水平将其分为未升高组、升高组和铅中毒组。进行了描述性和多变量分析。结果与BPb未升高组相比，铅中毒组QRS波高电压发生率高，RyR 1基因表达水平低（p<0.05）。进一步的非条件多变量logistic回归分析显示，在调整潜在混杂因素后，高QRS电压与BPb呈正相关（OR=1.045，95%CI 1.014至1.078），与RyR 1表达呈负相关（OR=0.042，95%CI 0.002至0.980）。此外，多元线性回归分析显示，校正潜在混杂因素后，QTc间期与ZPP呈正相关（β= 0. 299，95% CI 0. 130 - 0. 468）。结论职业性铅暴露可能与心电图异常（QRS波高）有关，可能与RyR 1水平降低有关。
Objectives A significant number of researches have evidenced that occupational lead (Pb) exposure increased risks of cardiovascular disease. However, evidences about the potential effects of Pb on the cardiac conduction system are sparse and inconclusive. Besides, ryanodine receptors (RyRs) induced dysfunction of cardiac excitation contraction coupling which is considered to be one of the mechanisms in cardiovascular diseases. Therefore, we examined the association between occupational Pb exposure and ECG conduction abnormalities, as well as RyRs in Pb-induced ECG abnormalities. Methods We investigated 529 Pb smelter workers, and measured blood lead (BPb), zinc protoporphyrin (ZPP), ECG outcomes and RyR expression levels. Based on BPb levels, the workers were divided into three groups: the BPb not elevated group, the BPb elevated group and the Pb poisoning group. Descriptive and multivariable analyses were performed. Results Compared with the BPb not elevated group, the Pb poisoning group had a higher incidence of high QRS voltage, and a lower level of RyR1 gene expression (p<0.05). Further unconditional multivariable logistic regression analyses showed that high QRS voltage was positively related to BPb (OR=1.045, 95% CI 1.014 to 1.078) and inversely associated with RyR1 expression (OR=0.042, 95% CI 0.002 to 0.980) after adjusting for potential confounders. In addition, multiple linear regression analyses showed that the QTc interval was positively associated with ZPP (β=0.299, 95% CI 0.130 to 0.468) after adjusting for potential confounders. Conclusions Our study provided evidences that occupational exposure to Pb may be associated with worse ECG outcomes (high QRS voltage), which might be related to decreased levels of RyR1.
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DOI：
10.1113/jphysiol.1994.sp020406
发表时间：
2005
期刊：
The Journal of Physiology
影响因子：
--
作者：
D. Lechardeur;M. Bardoul;F. Roux;D. Scherman
通讯作者：
D. Lechardeur;M. Bardoul;F. Roux;D. Scherman
影响因子：
37.8
作者：
Kushnir A;Santulli G;Reiken SR;Coromilas E;Godfrey SJ;Brunjes DL;Colombo PC;Yuzefpolskaya M;Sokol SI;Kitsis RN;Marks AR
通讯作者：
Marks AR
影响因子：
3.2
作者：
Ruilope, Luis M.;Schmieder, Roland E.
通讯作者：
Schmieder, Roland E.
DOI：
10.26616/nioshpub2009136
发表时间：
2009-04
期刊：
--
影响因子：
--
作者：
M. Barsan;M. Boeniger;K. Crouch;Eric J. Esswein;C. Kardous;Amir Khan;B. King;W. Murphy;R. Tubbs;E. Whelan;R. Willson
通讯作者：
M. Barsan;M. Boeniger;K. Crouch;Eric J. Esswein;C. Kardous;Amir Khan;B. King;W. Murphy;R. Tubbs;E. Whelan;R. Willson
影响因子：
1.4
作者：
J. M. Hanson;E. Kirkman;P. Duijvendijk;M. Goto
通讯作者：
J. M. Hanson;E. Kirkman;P. Duijvendijk;M. Goto