Shaping plasticity to enhance recovery after injury.
Shaping plasticity to enhance recovery after injury.
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DOI：
10.1016/b978-0-444-53355-5.00015-4
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发表时间：
2011
影响因子：
--
通讯作者：
Nudo, Randolph J.
中科院分区：
文献类型：
--
作者：
Dancause, Numa;Nudo, Randolph J.
过去十年的神经科学研究提供了相当多的证据，证明成人大脑在受伤后可以进行大量的重组。例如，在发生缺血性损伤后，比如中风后，会发生一系列分子、遗传、生理和解剖学事件，使大脑中剩余的结构得以重组。通常，这些事件与恢复有关，表明它们有助于恢复。事实上，“可塑性”一词在中风研究中一直具有积极的历史内涵。但最近，人们努力区分有益的变化和有害的变化。这些概念是及时的，因为神经康复研究正在开发新的治疗方法来调节、增加或抑制目标大脑区域的可塑性。我们将回顾可塑性的基本原理，以及目前正在研究的一些新的和令人兴奋的方法来塑造中枢神经系统损伤后的可塑性。
The past decade of neuroscience research has provided considerable evidence that the adult brain can undergo substantial reorganization following injury. For example, following an ischemic lesion, such as occurs following a stroke, there is a cascade of molecular, genetic, physiological and anatomical events that allows the remaining structures in the brain to reorganize. Often, these events are associated with recovery, suggesting that they contribute to it. Indeed, the term plasticity in stroke research has had a positive connotation historically. But more recently, efforts have been made to differentiate beneficial from detrimental changes. These notions are timely now that neurorehabilitative research is developing novel treatments to modulate, increase, or inhibit plasticity in targeted brain regions. We will review basic principles of plasticity and some of the new and exciting approaches that are currently being investigated to shape plasticity following injury in the central nervous system.