Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms.
Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms.
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DOI：
10.1038/s41598-018-24732-1
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发表时间：
2018-04-24
影响因子：
4.6
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Duan Z;Li Y;Guan S;Ma C;Han Y;Ren X;Wei L;Li W;Lou J;Yang Z
颅内小动脉瘤（SIAs，≤5mm）破裂危险因素的表征具有临床价值。本研究旨在确定与 SIA 破裂状态相关的基于图像的形态参数和解剖位置。纳入 263 例单发 SIA 患者（128 例破裂，135 例未破裂），采用三维几何学评估动脉瘤位置，包括尺寸、纵横比（AR）、尺寸比（SR）、高宽比（H/W）、血流角（FA）和动脉瘤宽度与载瘤动脉直径比等 6 个形态学参数，并 用于确定与动脉瘤破裂的相关性。单变量分析显示，破裂组和未破裂组之间的 AR、SR、H/W、FA 和动脉瘤位置存在统计学显着差异。 Logistic回归分析进一步显示，在调整年龄、性别和其他临床危险因素后，AR (p = 0.034)、SR (p = 0.004)、H/W (p = 0.003)和FA (p < 0.001)与破裂的SIA具有最强的独立相关性。未来一项针对更大 SIA 队列的研究需要确定 AR、SR、H/W 和 FA 在多大程度上增加了未破裂 SIA 患者的破裂风险（就绝对风险而言）。
Characterization of the rupture risk factors for small intracranial aneurysms (SIAs, ≤5 mm) is clinically valuable. The present study aims to identify image-based morphological parameters and anatomical locations associated with the rupture status of SIAs. Two hundred and sixty-three patients with single SIAs (128 ruptured, 135 unruptured) were included, and six morphological parameters, including size, aspect ratio (AR), size ratio (SR), height–width ratio (H/W), flow angle (FA) and aneurysm width–parent artery diameter ratio, and the aneurysm locations were evaluated using three-dimensional geometry, and were used to identify a correlation with aneurysm rupture. Statistically significant differences were observed between ruptured and unruptured groups for AR, SR, H/W, FA, and aneurysm locations, from univariate analyses. Logistic regression analysis further revealed that AR (p = 0.034), SR (p = 0.004), H/W (p = 0.003), and FA (p < 0.001) had the strongest independent correlation with ruptured SIAs after adjustment for age, gender and other clinical risk factors. A future study on a larger SIA cohort need to establish to what extent the AR, SR, H/W and FA increase the risk of rupture in patients with unruptured SIAs in terms of absolute risks.