Biomechanical effect of mineral heterogeneity in trabecular bone
Biomechanical effect of mineral heterogeneity in trabecular bone
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DOI：
10.1016/j.jbiomech.2008.07.009
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发表时间：
2008-09-18
影响因子：
2.4
通讯作者：
van Eijden, T. M. G. J.
中科院分区：
文献类型：
--
作者：
Renders, G. A. P.;Mulder, L.;van Eijden, T. M. G. J.
由于日常负荷，骨小梁会变形（即应变），从而导致骨组织产生应力。当应力和/或应变偏离正常范围时，重塑过程会导致骨结构及其矿化程度的适应，以有效承受持续变化的载荷。由于假定骨骼的表观机械性能取决于矿化程度和分布，因此本研究的目标是检查矿物质异质性对人类下颌骨髁小梁骨生物力学性能的影响。为此，使用 microCT 系统对人类齿状下颌骨的 9 个右髁进行扫描和评估。定义了感兴趣的立方区域体积，并将每个体积转换为两种不同类型的有限元 (FE) 模型，一种是同质的，一种是异质的。在异质模型中，元素组织模量根据局部矿化程度进行缩放，并使用 microCT 确定。模拟压缩和剪切测试以确定两种模型类型的表观弹性模量。与均质模型相比，矿化变化的结合使表观杨氏模量和剪切模量最大降低了 21%。异质模型表观模量与骨体积分数和矿化程度显着相关。结论是，忽视矿物的非均质性可能会导致有限元模型中表观弹性模量的显着高估。 (C) 2008 Elsevier Ltd. 保留所有权利。
Due to daily loading, trabecular bone is Subjected to deformations (i.e., strain), which lead to stress in the bone tissue. When stress and/or strain deviate from the normal range, the remodeling process leads to adaptation of the bone architecture and its degree of mineralization to effectively withstand the sustained altered loading. As the apparent mechanical properties of bone are assumed to depend on the degree and distribution of mineralization, the goal Of the Present Study was examine the influences of mineral heterogeneity on the biomechanical properties of trabecular bone in the human mandibular condyle. For this purpose nine right condyles from human dentate mandibles were scanned and evaluated with a microCT system. Cubic regional Volumes of interest were defined, and each was transformed into two different types of finite element (FE) models, one homogeneous and one heterogeneous. In the heterogeneous models the element tissue moduli were scaled to the local degree of mineralization, which was determined using microCT. Compression and shear tests were Simulated to determine the apparent elastic moduli in both model types. The incorporation of mineralization variation decreased the apparent Young's and shear moduli by maximally 21% in comparison to the homogeneous models. The heterogeneous model apparent moduli correlated significantly with bone volume fraction and degree of mineralization. It was concluded that disregarding mineral heterogeneity may lead to considerable overestimation of apparent elastic moduli in FE models. (C) 2008 Elsevier Ltd. All rights reserved.