PREVENTION IN RATS OF NARCOSIS PRODUCED BY INERT GASES AT HIGH PRESSURES
PREVENTION IN RATS OF NARCOSIS PRODUCED BY INERT GASES AT HIGH PRESSURES
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DOI：
10.1152/ajplegacy.1963.205.5.1013
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发表时间：
1963-01-01
影响因子：
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通讯作者：
BENNETT, PB
中科院分区：
文献类型：
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作者：
BENNETT, PB
描述了一种动物惰性气体麻醉定量评价技术。短句来源本实验以46只成年Wistar大鼠为实验对象，在口服、腹腔和静脉注射α（4聚苯乙烯基）苯并氢氯酸盐前后，测定12.6、13.5大气压氮气和12.6大气压氩气对轻度电击的麻醉作用。这种药物控制了这些惰性气体产生的麻醉作用，据观察，没有发生不良的副作用。有效剂量为40 mg （130 ~ 150 mg/kg体重）。较低剂量仅部分有效。最大的保护作用是在给药后48小时左右。
A technique is described for quantitative evaluation of inert gas narcosis in animals. The response of 46 adult Wistar rats to minimal electroshock was used fa 102 experiments to determine the narcotic effect of nitrogen at 12.6 and 13.5 atm abs and argon at 12.6 atm abs, before and after the oral, intraperitoneal, and intravenous administration of alpha (4 plperldyl) benzhydrol hydrochlorlde. The drug controlled the narcotic effect produced by these inert gases without, so far as could be observed, the occurrence of undesirable side effects. The effective dose was 40 mg (130-150 mg/kg body weight). Lower doses were only partially effective. The maximum protective action of the drag was some 48 hours after its administration.