Characteristics of the Symptoms of the Proposed ND-PAE Disorder in First Grade Children in a Community Sample.
Characteristics of the Symptoms of the Proposed ND-PAE Disorder in First Grade Children in a Community Sample.
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社区样本中一年级儿童拟议的 ND-PAE 疾病的症状特征。
DOI：
10.1007/s10578-022-01414-8
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发表时间：
2024
影响因子：
2.9
通讯作者：
Bandoli,Gretchen
中科院分区：
文献类型：
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作者：
Kable,JulieA;Coles,ClaireD;Holton,JenniferE;Kalberg,WendyO;May,PhilipA;Chambers,ChristinaD;Bandoli,Gretchen
在参与胎儿酒精谱系疾病患病率合作研究的儿童中评估了与产前酒精暴露相关的神经行为障碍 (ND-PAE) 的拟议症状。将有 ND-PAE“风险”的儿童 (n = 204) 与没有产前酒精暴露、酒精相关畸形或生长缺陷的儿童 (n = 908) 进行对比。症状是根据使用两个诊断阈值水平（1.0 和 1.5 STD）的神经心理学测试来定义的。处于 ND-PAE 风险的个体在 1.0 阈值时对自我调节和适应性障碍的认可率较高，在 1.5 阈值时对神经认知和自我调节障碍的认可率较高。在 1.0 阈值下，对该疾病的认可存在显着差异。接受者操作特征曲线分析表明，智商低于 70 并不能预测诊断，但智商标准的修改提高了预测有效性。如果没有 PAE 记录，区分效度很差，而 PAE 记录仍然是诊断 ND-PAE 的必要条件。
The proposed symptoms for Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE) were evaluated in children who participated in the Collaboration on Fetal Alcohol Spectrum Disorders Prevalence study. Children “at-risk” for ND-PAE (n = 204) were contrasted to children with no prenatal alcohol exposure, alcohol-related dysmorphia or growth deficits (n = 908). Symptoms were defined based on neuropsychological testing using two diagnostic threshold levels (1.0 and 1.5 STD). Individuals at risk for ND-PAE had higher endorsement rates of the self-regulation and adaptive impairments at the 1.0 threshold and of the neurocognitive and self-regulation impairments at the 1.5 threshold. Endorsement of the disorder significantly differed at the 1.0 threshold. Receiver operating characteristic curve analysis indicated that having an IQ below 70 was not predictive of the diagnosis but modifications of the IQ criterion improved predictive validity. Discrimination validity was poor without documentation of PAE which continues to be a necessity for a diagnosis of ND-PAE.