Pregnancy and risk of renal cell cancer: a population-based study in Sweden
Pregnancy and risk of renal cell cancer: a population-based study in Sweden
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DOI：
10.1038/sj.bjc.6600263
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发表时间：
2002-05-06
影响因子：
8.8
通讯作者：
Hsieh, CC
中科院分区：
文献类型：
--
作者：
Lambe, M;Lindblad, P;Hsieh, CC
流行病学研究结果表明，荷尔蒙的影响可能在肾细胞癌(RCC)的病因中起作用，生育的可能影响仍然是个谜；一些研究人员报告了出生数量与肾细胞癌风险之间的正相关，而另一些研究人员则没有。一项病例对照研究嵌套在全国生育登记中，涵盖了1925年及以后出生的瑞典妇女，旨在探索第一次出生时的生育和年龄与肾细胞癌风险之间的可能联系。在这些妇女中，在1958年至1992年期间，瑞典癌症登记处共确认了1465例肾细胞癌病例，并通过与生育率数据库的链接获得了有关活产婴儿数量和每次出生年龄的信息。对于每个病例，从相同的登记中随机选择五个年龄匹配的对照。与未分娩的妇女相比，曾经经产的妇女患肾癌的风险增加40%(优势比[OR]=1.42；95%可信区间1.19-1.69)。胎次高(活产5次或以上)的相应OR为1.91(95%可信区间1.40~2.62)。在控制了产妇的第一胎年龄后，每多生一胎风险增加15%(OR=1.15；95%可信区间1.08-1.22)。观察到的产次与肾细胞癌风险之间的正相关不太可能完全用不受控制的混淆来解释，但需要在大型研究中进行进一步评估，并考虑体重指数。(C)2002年英国癌症研究中心。
Epidemiological findings indicate that hormonal influences may play a role in the etiology of renal cell cancer (RCC), The possible effect of childbearing remains enigmatic; while some investigators have reported a positive association between number of births and renal cell cancer risk, others have not. A case-control study, nested within a nation-wide Fertility Register covering Swedish women born 1925 and later, was undertaken to explore possible associations between parity and age at first birth and the risk of renal cell cancer. Among these women a total of 1465 cases of RCC were identified in the Swedish Cancer Register between 1958 and 1992 and information on the number of live childbirths and age at each birth was obtained by linkage to the Fertility Database. For each case, five age-matched controls were randomly selected from the same register. Compared to nulliparous women, ever-parous women were at a 40% increased risk of RCC (Odds Ratio [OR]=1.42; 95% Cl 1.19-1.69). The corresponding OR for women of high parity (five or more live births) was 1.91 (95% Cl 1.40-2.62). After controlling for age at first birth among parous women, each additional birth was associated with a 15% increase in risk (OR=1.15; 95% Cl 1.08-1.22). The observed positive association between parity and renal cell cancer risk is unlikely to be fully explained by uncontrolled confounding, but war-ants further evaluation in large studies, with allowance for body mass index. (C) 2002 Cancer Research UK.