Synchronization of Firing in Cortical Fast-Spiking Interneurons at Gamma Frequencies: A Phase-Resetting Analysis
Synchronization of Firing in Cortical Fast-Spiking Interneurons at Gamma Frequencies: A Phase-Resetting Analysis
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DOI：
10.1371/journal.pcbi.1000951
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发表时间：
2010-09-01
影响因子：
4.3
通讯作者：
Robinson, Hugh P. C.
中科院分区：
文献类型：
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作者：
Gouwens, Nathan W.;Zeberg, Hugo;Robinson, Hugh P. C.
新皮层中的快速尖峰（FS）细胞通过抑制性化学突触和电突触或间隙连接相互连接。FS神经元的同步放电在伽马振荡的产生中是重要的，频率在30和80 Hz之间。为了理解这些突触相互作用如何控制同步，在FS细胞中注入人工突触电导，并测量突触相位重置函数（SPRF），该函数描述了复合突触输入如何扰动作为其应用的相位的函数的γ频率尖峰的相位。GABA能和间隙连接电导对SPRF有明显的贡献，SPRF具有令人惊讶的简单的分段线性形式，在相位延迟和提前之间具有急剧的周期中断。SPRF的分析表明，FS神经元及其相互连接的内在生物物理特性如何允许在宽的伽马频带上夹带放电，其频率上限和下限分别由电突触和GABA能抑制控制。
Fast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic interactions control synchronization, artificial synaptic conductances were injected in FS cells, and the synaptic phase-resetting function (SPRF), describing how the compound synaptic input perturbs the phase of gamma-frequency spiking as a function of the phase at which it is applied, was measured. GABAergic and gap junctional conductances made distinct contributions to the SPRF, which had a surprisingly simple piecewise linear form, with a sharp midcycle break between phase delay and advance. Analysis of the SPRF showed how the intrinsic biophysical properties of FS neurons and their interconnections allow entrainment of firing over a wide gamma frequency band, whose upper and lower frequency limits are controlled by electrical synapses and GABAergic inhibition respectively.