Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament
Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament
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DOI：
10.1177/2192568218801015
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发表时间：
2019-08-01
影响因子：
2.4
通讯作者：
Kimura, Tomoatsu
中科院分区：
文献类型：
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作者：
Kawaguchi, Yoshiharu;Kitajima, Isao;Kimura, Tomoatsu
研究设计：病例对照研究。目的：从血清成纤维细胞生长因子23(FGF23)水平探讨后纵韧带骨化(OPLL)的可能发病机制。方法：本研究包括95例OPLL患者和73名年龄和性别匹配的志愿者作为对照组。测定血中成纤维细胞生长因子-23、肌酐(Cre)、碱性磷酸酶、钙(Ca)、无机磷(PI)和超敏C反应蛋白(hs-CRP)浓度，尿样测定Cre、Ca、PI和肾小管磷酸盐重吸收。根据骨化指数(OP指数和OS指数)评价OPLL患者脊柱骨化病变的严重程度。比较OPLL组和对照组以及OPLL进展组和无进展组之间的数据。结果：OPLL患者血清FGF23、hs-CRP高于正常对照组，PI低于正常对照组。血清PI与OS指数呈负相关，但相关性很弱。总体而言，31.7%的患者在随访期间发生了OPLL的进展。FGF23和hs-CRP在进展组高于无进展组。结论：FGF23和hs-CRP可能是OPLL的阳性标记物。通过成纤维细胞生长因子-23的磷酸盐代谢可能是未来研究OPLL发病机制的一个靶点。
Study Design: Case-control study. Objectives: To determine the possible pathogenesis of ossification of the posterior longitudinal ligament (OPLL) in regard to the serum concentration of fibroblast growth factor 23 (FGF-23). Methods: The study included 95 patients with OPLL and a control group of 73 age- and sex-matched volunteers. The serum concentrations of FGF-23, creatinine (Cre), alkaline phosphatase, calcium (Ca), inorganic phosphate (Pi), and hypersensitive C-reactive protein (hs-CRP) were analyzed from blood samples, and Cre, Ca, Pi, and tubular reabsorption of phosphate were measured using urine samples. We evaluated the severity of ossified spinal lesions in patients with OPLL according to the ossification index (the OP index and the OS index). Data was compared between the OPLL and control group and between the OPLL progression and no progression group. Results: Serum FGF-23 and hs-CRP were higher, and serum Pi was lower in patients with OPLL than in the controls. There was a positive correlation between FGF-23 and hs-CRP and a negative correlation between serum Pi and the OS index; however, the correlations were very weak. Overall, 31.7% of patients had progression of OPLL during follow-up. FGF-23 and hs-CRP were higher in the progression group than in the no progression group. Conclusions: These results might indicate that FGF-23 and hs-CRP are positive markers for OPLL. Phosphate metabolism via FGF-23 might be a target for future study on the pathogenesis of OPLL.