Characteristics and Significance of the Pre-metastatic Niche
Characteristics and Significance of the Pre-metastatic Niche
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DOI：
10.1016/j.ccell.2016.09.011
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发表时间：
2016-11-14
期刊：
影响因子：
50.3
通讯作者：
Cao, Xuetao
中科院分区：
文献类型：
--
作者：
Liu, Yang;Cao, Xuetao
原发肿瘤在继发器官和组织部位为后续转移创造了有利的微环境，即转移前生态位。转移前生态位可以通过原发肿瘤源性因子、肿瘤动员的骨髓源性细胞和局部基质成分之间的复杂相互作用来启动和建立。我们在这里回顾了我们目前对转移前生态位形成的关键成分和潜在机制的理解。我们提出了确定转移前生态位的六个特征，包括免疫抑制、炎症、血管生成/血管通透性、淋巴管生成、器官亲和性和重编程，这些特征可以使肿瘤细胞定植并促进转移。我们强调了转移前生态位的重要性，并讨论了潜在的影响和未来的研究方向。
Primary tumors create a favorable microenvironment, namely, pre-metastatic niche, in secondary organs and tissue sites for subsequent metastases. The pre-metastatic niche can be primed and established through a complex interplay among primary tumor-derived factors, tumor-mobilized bone marrow-derived cells, and local stromal components. We review here our current understanding of the key components and underlying mechanisms for pre-metastatic niche formation. We propose six characteristics that define the pre-metastatic niche, which enable tumor cell colonization and promote metastasis, including immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, and reprogramming. We highlight the significance of the pre-metastatic niche, and discuss potential implications and future research directions.