Dopamine selective molecularly imprinted polymers via post-imprinting modification
Dopamine selective molecularly imprinted polymers via post-imprinting modification
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DOI：
10.1039/b514432a
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发表时间：
2006-02-07
影响因子：
3.2
通讯作者：
Shinmori, H
中科院分区：
文献类型：
--
作者：
Takeuchi, T;Murase, N;Shinmori, H
利用共价印迹法制备了一种新的多巴胺受体，该受体带有双齿结合位点，二硫键被切割并氧化为非共价亚砜识别基团。所使用的模板具有通过二硫化物连接到烯丙基部分和通过环状硼酸二酯连接到4-乙烯基苯基的多巴胺样结构。聚合后，水解酯键并还原二硫键以从聚合物基质中除去模板部分，然后氧化以将硫醇残基转化为磺酸（后印迹过程）。该印迹聚合物在水溶液中选择性地吸附多巴胺，主要通过两点作用，即与磺酸残基形成环状硼酸二酯和静电作用。
A novel synthetic dopamine receptor bearing bidentate binding sites were prepared by covalent imprinting using a disulfide linkage which is cleaved and oxidized to a non-covalent sulfoxide recognition group. The used templates have dopamine-like structures connected to an allyl moiety via a disulfide and to a 4-vinylphenyl group via a cyclic boronic diester. After the polymerization, the ester bonds were hydrolyzed and the disulfide bond was reduced to remove the template moiety from the polymer matrix, followed by the oxidation to transform the thiol residues into sulfonic acid (post imprinted process). The imprinted polymer adsorbed dopamine selectively in aqueous solution with the two-point interaction, i.e. the formation of cyclic boronic diester and electrostatic interaction with the sulfonic acid residue.