CHRONIC NERVE COMPRESSION MODEL FOR THE DOUBLE CRUSH HYPOTHESIS
CHRONIC NERVE COMPRESSION MODEL FOR THE DOUBLE CRUSH HYPOTHESIS
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DOI：
10.1097/00000637-199103000-00008
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发表时间：
1991-03-01
影响因子：
1.5
通讯作者：
MACKINNON, SE
中科院分区：
文献类型：
--
作者：
DELLON, AL;MACKINNON, SE
“双重挤压假说”是一个基于Upton和McComas在1973年提出的假说而进入临床使用的短语。虽然双重挤压的临床例子越来越多地出现，但这一假说还没有实验证明，因为它与慢性神经压迫有关。本研究采用大鼠坐骨神经最小环扎模型，观察单带或双带同时放置或时间间隔放置对大鼠神经电生理功能的影响。这项研究证实，存在两个同时受压的部位，或第二个(后)受压部位，放置在第一个(较早)受压部位的近端或远端，将导致明显低于单一受压部位的神经功能。
"Double crush hypothesis" is a phrase that has entered clinical use based on a hypothesis presented by Upton and McComas in 1973. Although clinical examples of the double crush are appearing more frequently, there has been no experimental proof of this hypothesis as it relates to chronic nerve compression. This study used a model of sciatic nerve minimal banding in the rat to investigate the effect on electrophysiological function of single or double band placement, concurrently or separated in time. This study confirms that the existence of two sites of simultaneous compression, or a second (later) site of compression, placed either proximal or distal to the first (earlier) site of compression, will result in significantly poorer neural function than will a single site of compression.