High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus
High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus
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DOI：
10.1111/j.1365-2265.2008.03306.x
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发表时间：
2009-02-01
影响因子：
3.2
通讯作者：
Voorbij, Hieronymus A. M.
中科院分区：
文献类型：
--
作者：
Dullaart, Robin P. F.;de Vries, Rindert;Voorbij, Hieronymus A. M.
在2型糖尿病中，循环C反应蛋白(CRP)增加，而与高密度脂蛋白(HDL)相关的抗氧化和抗炎酶对氧磷酶-I降低。高C反应蛋白和低对氧磷酶-I活性均可预测心血管疾病。目前尚不清楚对氧磷酶-I活性降低是否与糖尿病患者的C反应蛋白水平升高有关。在81例2型糖尿病患者和89例对照组中，测定了高敏C反应蛋白、血清对氧磷酶-I活性(芳香酯酶活性，用苯乙酸苯酯水解率测定)、血浆瘦素、脂联素、抵抗素和血脂。0.001)，而高密度脂蛋白胆固醇、对氧磷酶-I活性和脂联素水平低于对照组(P=0.02P<；0.001)。多元线性回归分析显示，在控制了年龄和性别后，C反应蛋白与对氧磷酶-I活性(β=-0.15，P=0.028)和脂联素(β=-0.18，P=0.009)呈负相关，与瘦素(β=0.33，P&t；0.001)和体重指数(β=0.22，P=0.007)呈正相关，与糖尿病状态(或空腹血糖或HbA1c)、胰岛素抵抗和血脂(P&gT；低对氧磷酶-I活性与较高的C反应蛋白有关，与脂肪因子无关，也与肥胖和血脂无关。2型糖尿病患者对氧磷酶-I活性低可能通过对增强的全身低度炎症的影响而增加心血管风险。
In type 2 diabetes mellitus, circulating C-reactive protein (CRP) is increased, whereas the high density lipoprotein (HDL)-associated, anti-oxidative and anti-inflammatory enzyme, paraoxonase-I, is decreased. Both high CRP and low paraoxonase-I activity may predict cardiovascular disease. It is unknown whether lower paraoxonase-I activity contributes to higher CRP levels in diabetes. In type 2 diabetic and control subjects, we determined the relationship of CRP with paraoxonase-I when taking account of plasma levels of pro- and anti-inflammatory adipokines.In 81 type 2 diabetic patients and 89 control subjects, plasma high-sensitive CRP, serum paraoxonase-I activity (arylesterase activity, assayed as the rate of hydrolysis of phenyl acetate into phenol), plasma leptin, adiponectin, resistin and lipids were determined.Body mass index (BMI), waist, insulin resistance, triglycerides, CRP, leptin and resistin levels were higher (P < 0.05 to P < 0.001), whereas HDL cholesterol, paraoxonase-I activity and adiponectin levels were lower (P = 0.02 to P < 0.001) in diabetic compared to control subjects. Multiple linear regression analysis demonstrated that, after controlling for age and gender, CRP was inversely related to paraoxonase-I activity (beta = -0.15, P = 0.028) and adiponectin (beta = -0.18, P = 0.009), and positively to leptin (beta = 0.33, P < 0.001) and BMI (beta = 0.22, P = 0.007), independently of the diabetic state (or of fasting glucose or HbA1c), insulin resistance and lipids (P > 0.20 for all).low paraoxonase-I activity is related to higher CRP, independently of adipokines, as well as of obesity and lipids. Low paraoxonase-I activity in type 2 diabetes mellitus may contribute to increased cardiovascular risk via an effect on enhanced systemic low-grade inflammation.