Neutrophil ion currents matter.
Neutrophil ion currents matter.
复制标题
中性粒细胞离子流很重要。
DOI：
10.1093/cvr/cvac025
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发表时间：
2022
影响因子：
10.8
通讯作者：
Ley,Klaus
中科院分区：
文献类型：
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作者：
Ley,Klaus
中性粒细胞不是可兴奋的细胞，但离子电流对它们的功能很重要。Immler等人1表明，电压门控钾通道Kv1. 3（基因名称Kcna3）对中性粒细胞功能至关重要。这一新发现补充了先前的工作，表明细胞内游离钙[Ca2 +] i对许多中性粒细胞功能的关键作用。钙库操纵的钙通道（SOCE）2和钙释放激活的钙通道（CRAC）3早已被认为参与调节[Ca2 +] i。髓样细胞还表达瞬时受体电位通道，其与炎症功能有关。4但Kv1的作用。3的不同之处在于该通道不直接调节钙流。
Neutrophils are not excitable cells, yet ion currents matter for their function. Immler et al. 1 show that the voltage-gated potassium channel Kv1. 3 (gene name Kcna3) is critical for neutrophil function. This new discovery complements previous work showing the key role of intracellular free calcium [Ca2þ] i for many neutrophil functions. Store-operated calcium channels (SOCE) 2 and calcium release-activated calcium (CRAC) channels 3 have long been known to be involved in regulating [Ca2þ] i. Myeloid cells also express transient receptor potential channels that have been implicated in inflammatory functions. 4 But the role of Kv1. 3 is different in that this channel does not directly regulate calcium flux.