Relating structure to function in vivo with tomographic imaging.
Relating structure to function in vivo with tomographic imaging.
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通过断层扫描成像将体内结构与功能联系起来。
DOI：
10.1002/9780470514184.ch6
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Toga,AW
中科院分区：
文献类型：
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作者：
Mazziotta,JC;Valentino,D;Grafton,S;Bookstein,F;Pelizzari,C;Chen,G;Toga,AW
为了评估大脑的正常生理反应或伴随疾病状态的病理生理变化，有必要比较个体受试者不同成像方式之间的数据集。同样，对个体受试者在成像模式内和跨成像模式之间的数据进行比较也很重要。在与一些大学团体的合作项目中，我们开发了一个系统，该系统允许对同一个人从不同模式获得的三维数据集进行主题内对齐和注册。该分析考虑了图像采集、配准和对准在缩放、平移和旋转方面引起的误差。一个更困难的问题是个体大脑解剖的主体间扭曲，以匹配另一个个体或理想化的模型。如果应用形态计量学和同源地标的原理，三维脑翘曲可以提供这种类型的受试者之间的比较。完成这两项任务的结果是一个系统，该系统允许从特定个体中获得的数据在结构和功能上进行比较，分别从磁共振成像（MRI）和正电子发射断层扫描（PET）中获得。它还允许将结果信息与来自正常个体或患有特定神经系统疾病的患者群体的平均受试者数据进行比较。该系统提供了一种客观和自动化的方式来比较个人之间的定量数据的方法。
For the normal physiological responses of the brain or the pathophysiological changes that accompany disease states to be evaluated, it is necessary to compare data sets between different imaging modalities for individual subjects. Similarly, it is important to compare data between individuals both within and across imaging modalities for individual subjects. In a collaborative project with a number of university groups we have developed a system that allows for the within‐subject alignment and registration of three‐dimensional data sets obtained from different modalities for the same individual. This analysis takes into account the error induced by image acquisition, registration and alignment with regard to scaling, translation and rotation. A more difficult problem is the between‐subject warping of individual brain anatomy to match that of another individual or of an idealized model. If the principles of morphometrics and homologous landmarks are applied, three‐dimensional brain warping can provide this type of between‐subject comparison. The result of accomplishing these two tasks is a system that allows data obtained in a given individual to be compared across structure and function, as obtained from magnetic resonance imaging (MRI) and from positron emission tomography (PET), respectively. It also allows comparison of the resultant information with averaged between‐subject data from populations of normal individuals or patients with specific neurological disorders. This system provides the means by which to compare quantitative data between individuals in an objective and automated fashion.