Clear cell adenocarcinoma of the endometrium is a biologically distinct entity from endometrioid adenocarcinoma
Clear cell adenocarcinoma of the endometrium is a biologically distinct entity from endometrioid adenocarcinoma
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DOI：
10.1111/j.1525-1438.2006.00494.x
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发表时间：
2006-01-01
影响因子：
4.8
通讯作者：
Kuramoto, H
中科院分区：
文献类型：
--
作者：
Arai, T;Watanabe, J;Kuramoto, H
子宫内膜透明细胞腺癌（CCA）的预后较差，尽管这种罕见肿瘤的生物学特征尚不清楚。在这项研究中，我们分析了与癌发生、肿瘤生长和进展相关的生物标志物的表达。将 13 例 CCA 病例与子宫内膜子宫内膜样腺癌 (EMA) 病例进行比较。 p53 的免疫组织化学染色； Ki-67；细胞周期蛋白 A、D1 和 E； E-钙粘蛋白；黄体酮受体（PR）-A和PR-B； P-糖蛋白； MLH1；并进行了MSH2。 CCA 中 p53、Ki-67 和细胞周期蛋白 A、D1 和 E 的标记指数分别为 46.4 +/- 24.3%、52.1 +/- 20.5%、37.9 +/- 21.4%、12.3 +/- 27.9% 和 8.2 +/- 22.9%。 E-钙粘蛋白仅在 1 例 (7.7%) 的 CCA 中表达，而 39 例 (61.0%) 的 EMA 中有表达。 PR-A 和 PR-B 的 CCA 均未呈阳性。 7例（53.8%）检出P-糖蛋白。 8 例 (61.5%) 发生 MLH1 或 MSH2 表达缺失。与 EMA 相比，CCA 中观察到 p53、细胞周期蛋白 A 和 P-糖蛋白高水平表达，而细胞周期蛋白 E、E-钙粘蛋白、PR-A 和 PR-B 低水平表达或无表达。子宫内膜CCA的细胞周期调控机制与EMA不同，可能影响其恶性潜能。子宫内膜 CCA 是与 EMA 不同的实体。
Clear cell adenocarcinoma (CCA) of the endometrium has a poor prognosis, although the biologic features of this rare tumor are not clear. In this study, we analyzed the expression of biologic markers relating to carcinogenesis, tumor growth, and progression. Thirteen cases of CCA were compared with cases of endometrioid adenocarcinoma (EMA) of the endometrium. Immunohistochemical staining for p53; Ki-67; cyclins A, D1, and E; E-cadherin; progesterone receptor (PR)-A and PR-B; P-glycoprotein; MLH1; and MSH2 was performed. Labeling indices of p53, Ki-67, and cyclins A, D1, and E in CCA were 46.4 +/- 24.3%, 52.1 +/- 20.5%, 37.9 +/- 21.4%, 12.3 +/- 27.9%, and 8.2 +/- 22.9%, respectively. E-cadherin was expressed in only 1 case (7.7%) of CCA, as compared to 39 cases (61.0%) of EMA. No CCAs were positive for PR-A and PR-B. P-glycoprotein was detected in seven cases (53.8%). Loss of either MLH1 or MSH2 expression occurred in eight cases (61.5%). High-level expression of p53, cyclin A, and P-glycoprotein, and low-level or no expression of cyclin E, E-cadherin, PR-A, and PR-B was observed in CCA compared with EMA. The mechanism of cell-cycle regulation in endometrial CCA is different from that in EMA and may influence its malignant potential. Endometrial CCA is a distinct entity from EMA.