Variability of aerosol delivery via spacer devices in young asthmatic children in daily life
Variability of aerosol delivery via spacer devices in young asthmatic children in daily life
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DOI：
10.1034/j.1399-3003.1999.13d15.x
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发表时间：
1999-04-01
影响因子：
24.3
通讯作者：
Tiddens, HAWM
中科院分区：
文献类型：
--
作者：
Janssens, HM;Devadason, SG;Tiddens, HAWM
加压定量吸入器（pMDI）广泛与间隔剂一起用于治疗儿童哮喘，然而，pMDI/间隔剂组合的每日药物剂量的变异性尚不清楚。静电荷是剂量变异性的潜在来源。金属垫片不带静电，本研究评估并比较了金属垫片和塑料垫片气雾剂给药的受试者内变异性，这是一项在1-4岁稳定型哮喘儿童中进行的随机交叉研究（I组，n=17）和5-8（组II，n=16）岁，在两组中，通过金属间隔器递送到口腔的药物量（Nebuchamber（R））和两种塑料（聚碳酸酯）间隔物中的一种，即组I中的Babyhaler（R）和组II中的VolumaeTM（R），使用布地奈德（200 μ g b.i.d.），以随机顺序在家中对金属和塑料间隔物进行测试，每次7天。将气溶胶收集在定位在间隔物和面罩或嘴之间的过滤器上。通过高效液相色谱法评估过滤器上的布地奈德。7天内每名儿童的平均滤器剂量（平均值+/-SD）表示为标称剂量的百分比。受试者内的变异性表示为变异系数（CV）。第I组的平均滤器剂量为41.7 ± 10.1%（雾化室）和26.0 ± 4.0%（Babyhaler）（p
Pressurized metered dose inhalers (pMDI) are widely used together with spacers for the treatment of asthma in children, However, the variability of daily medication dose for pMDI/spacer combinations is not known. Electrostatic charge is a potential source of dose variability. Metal spacers have no static charge, This study assessed and compared within-subject variability of aerosol delivery of metal and plastic spacers, This was a randomized, crossover study in children with stable asthma aged 1-4 (group I, n=17) and 5-8 (group II, n=16) yrs, In both groups the amount of drug delivered to the mouth by a metal spacer (Nebuchamber(R)) and one of two plastic (polycarbonate) spacers, i.e. Babyhaler(R) in group I and Volumatici(R) in group II was measured, The metal and plastic spacers mere tested at home in a randomized order for 7 days each, using budesonide (200 mu g b.i.d.). Aerosol was collected on a filter positioned between spacer and facemask or mouth. Budesonide on the filter was assessed by high performance liquid chromatography. The mean filter dose for each child (mean+/-SD) during the 7 days was expressed as a percentage of the nominal dose. Within-subject variability was expressed as coefficient of variation (CV).Mean filter dose in group I was 41.7+/-10.1% for Nebuchamber and 26.0+/-4.0% for Babyhaler (p