Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD.
Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD.
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DOI：
10.3389/fsurg.2021.753056
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发表时间：
2021
影响因子：
1.8
通讯作者：
He X
中科院分区：
文献类型：
--
作者：
Chen S;Wang T;Luo T;He S;Huang C;Jia Z;Zhan L;Wang D;Zhu X;Guo Z;He X
背景：在肝移植中，早期同种异体移植物功能障碍(EAD)与患者或移植物存活率低有关。然而，EAD的不同定义在预测移植物存活方面的作用尚不清楚。方法：这项单中心的回顾性研究回顾了2015年7月至2020年6月间接受原位肝移植的677例受者的数据。比较了以下EAD定义：移植后肝移植评估(L-GREGET)风险评分模型、早期同种异体移植失败简化评估评分(EASE)、早期同种异体移植功能模型评分和Olthoff标准。采用单因素和多因素Logistic回归分析对L-GrAFT7高危人群的危险因素进行评估。结果：L-GRAAFT7在预测移植物3个月存活率方面的C统计量为0.87，显著优于MEAF(C统计量=0.78，P=0.01)和EAD(C统计量=0.75，P<；0.001)。L-GrAFT10、EASE与L-GrAFT7相似，在预测生存方面无统计学意义。实验室模型、终末期肝病评分和冷缺血时间是L-GrAFT7高危人群的危险因素。结论：在中国队列中，L-GRAAFT7风险评分能够比MEAF和EAD更好地预测移植物的3个月存活率，可能会标准化早期移植物功能的评估，并作为临床试验的替代终点。
Background: Early allograft dysfunction (EAD) is correlated with poor patient or graft survival in liver transplantation. However, the power of distinct definitions of EAD in prediction of graft survival is unclear. Methods: This retrospective, single-center study reviewed data of 677 recipients undergoing orthotopic liver transplant between July 2015 and June 2020. The following EAD definitions were compared: liver graft assessment following transplantation (L-GrAFT) risk score model, early allograft failure simplified estimation score (EASE), model for early allograft function (MEAF) scoring, and Olthoff criteria. Risk factors for L-GrAFT7 high risk group were evaluated with univariate and multivariable logistic regression analysis. Results: L-GrAFT7 had a satisfied C-statistic of 0.87 in predicting a 3-month graft survival which significantly outperformed MEAF (C-statistic = 0.78, P = 0.01) and EAD (C-statistic = 0.75, P < 0.001), respectively. L-GrAFT10, EASE was similar to L-GrAFT7, and they had no statistical significance in predicting survival. Laboratory model for end-stage liver disease score and cold ischemia time are risk factors of L-GrAFT7 high-risk group. Conclusion: L-GrAFT7 risk score is capable for better predicting the 3-month graft survival than the MEAF and EAD in a Chinese cohort, which might standardize assessment of early graft function and serve as a surrogate endpoint in clinical trial.
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影响因子：
25.7
作者：
Agopian, Vatche G.;Markovic, Daniela;Busuttil, Ronald W.
通讯作者：
Busuttil, Ronald W.
DOI：
10.1111/j.1440-1746.2011.06844.x
发表时间：
2012-03-01
影响因子：
4.1
作者：
de Graaf, Esther L.;Kench, James;Verran, Deborah J.
通讯作者：
Verran, Deborah J.
DOI：
10.1016/j.hbpd.2019.02.005
发表时间：
2019-10-01
影响因子：
3.3
作者：
Bastos-Neves, Douglas;de Oliveira Salvalaggio, Paolo Rogerio;de Almeida, Marcio Dias
通讯作者：
de Almeida, Marcio Dias
影响因子：
65.1
作者：
Zarrinpar, Ali;Busuttil, Ronald W.
通讯作者：
Busuttil, Ronald W.
影响因子：
8.8
作者：
Croome, K. P.;Lee, D. D.;Taner, C. B.
通讯作者：
Taner, C. B.