Imaging neuroinflammation in Alzheimer's disease and other dementias: Recent advances and future directions
Imaging neuroinflammation in Alzheimer's disease and other dementias: Recent advances and future directions
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DOI：
10.1016/j.jalz.2014.08.105
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发表时间：
2015-09-01
影响因子：
14
通讯作者：
Edison, Paul
中科院分区：
文献类型：
--
作者：
Varley, James;Brooks, David J.;Edison, Paul
阿尔茨海默病（AD）、路易体痴呆、额颞叶痴呆（FTD）和亨廷顿病（HD）是痴呆的主要神经退行性病因。这些疾病的原因和机制仍然难以捉摸。神经炎症越来越多地成为其发展中的重要病理因素。使用[C-11] PK 11195的正电子发射断层扫描（PET）代表了一种通过转运蛋白（TSPO）可视化神经炎症的小胶质细胞组分的方法，我们讨论了这在神经退行性疾病中产生的有价值的见解。我们讨论了这种方法的局限性和第二代TSPO PET配体的发展，希望克服这些局限性。我们还讨论了可视化神经炎症的其他方法，并回顾了目前针对神经炎症的痴呆症治疗的状态。我们认为，对AD、帕金森病痴呆、FTD和HD中神经炎症的多模式研究将产生有价值的病理学见解，这将有助于开发治疗靶点和生物标志物。(C)2015年，阿尔茨海默氏症协会。爱思唯尔公司出版All rights reserved.
Alzheimer's disease (AD), dementia with Lewy bodies, frontotemporal dementia (FTD), and Huntington's disease (HD) are the main neurodegenerative causes of dementia. Causes and mechanisms of these diseases remain elusive. Neuroinflammation is increasingly emerging as an important pathological factor in their development. Positron emission tomography (PET) using [C-11]PK11195 represents a method of visualizing the microglial component of neuroinflammation via the translocator protein (TSPO) and we discuss the valuable insights this has yielded in neurodegenerative diseases. We discuss the limitations of this method and the development of second generation TSPO PET ligands which hope to overcome these limitations. We also discuss other methods of visualizing neuroinflammation and review the state of current dementia treatments targeted at neuroinflammation. It is our view that a multimodal investigation into neuroinflammation in AD, Parkinson's disease dementia, FTD and HD will yield valuable pathological insights which will usefully inform development of therapeutic targets and biomarkers. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.