Improvement of dry mouth following intraductal irrigation of salivary glands
Improvement of dry mouth following intraductal irrigation of salivary glands
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DOI：
10.1111/odi.13152
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发表时间：
2019-08-01
期刊：
影响因子：
3.8
通讯作者：
Almoznino, Galit
中科院分区：
文献类型：
--
作者：
Aframian, Doron J.;Baaton, Sagit;Almoznino, Galit
目的评价大涎腺导管内冲洗对口腔干燥的疗效。方法回顾性分析2013-2015年行大涎腺IG治疗的口干患者的病历。记录包括人口统计学、医学背景、口干病因学和口腔病学，以及唾液腺测量和唾液腺锥形束计算机断层扫描的结果。记录IG程序后的主观改善（是/否）和持续的主观改善（口干缓解>= 1个月）。通过比较IG前后的平均非刺激（USF）和刺激（SSF）全唾液流（WSF）率来评估客观改善。结果共纳入74例患者[平均年龄：59.08 ± 12.46岁]。在USF中检测到改善（p = 0.027），但在SSF中未检测到改善（p = 0.878）。55例（84.6%）观察到主观改善，10例（15.4%）未观察到主观改善。主观改善与IG后USF（p = 0.037）、唾液腺肿胀发作（p = 0.033）和吞咽干燥食物困难（p = 0.014）呈正相关。在主观改善的患者中，45例（81.8%）报告持续改善，这与缺乏砂砾感（p = 0.042）和异常涎腺CBCT结果（p = 0.001）呈正相关。结论大唾液腺IG是一种简单、安全的手术方法，可在较长时间内缓解口干症状。需要进一步的研究来证实这些初步发现并评估其潜在机制。
Objectives To assess the effect of major salivary gland intraductal irrigations (IGs) to relieve mouth dryness. Methods We retrospectively analyzed the records of patients with mouth dryness who underwent major salivary gland IG during 2013-2015. Records included demographics, medical background, dry mouth etiologies and symptomatology, and results of sialometry and sialo-cone-beam computerized tomography. Subjective improvement following the IG procedure (yes/no) and sustained subjective improvement (mouth dryness relief for >= 1 month) were recorded. Objective improvement was assessed by comparing the mean unstimulated (USF) and stimulated (SSF) whole salivary flow (WSF) rate before and after the IG. Results Seventy-four patients were included [mean age: 59.08 +/- 12.46 years]. Improvement was detected in the USF (p = .027), but not in the SSF (p = .878). Fifty-five (84.6%) noted subjective improvement, while 10 (15.4%) did not. Subjective improvement was positively associated with the USF following IG (p = .037), with salivary gland swelling episodes (p = .033), and with difficulties in swallowing dry foods (p = .014). Of those with subjective improvement, 45 (81.8%) reported sustained improvement, which was positively associated with lack of a gritty eye sensation (p = .042) and abnormal sialo-CBCT findings (p = .001). Conclusions Major salivary gland IG is a simple and safe procedure that may relieve dry mouth for a relatively extended duration. Further studies are needed to confirm these preliminary findings and assess their underlying mechanisms.