Genomically humanized mice: technologies and promises.
Genomically humanized mice: technologies and promises.
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DOI：
10.1038/nrg3116
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发表时间：
2011-12-16
期刊：
影响因子：
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通讯作者：
Fisher EM
中科院分区：
文献类型：
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作者：
Devoy A;Bunton-Stasyshyn RK;Tybulewicz VL;Smith AJ;Fisher EM
小鼠模型已经成为了解人类健康和疾病的宝贵工具，因为我们有能力精细地操纵小鼠基因组。基因组分析的最新进展导致检测到的致病突变的数量和类型增加，并且还突出了非编码区的重要性。因此，人们对创建“基因组学”人源化小鼠模型的兴趣越来越大，其中整个人类基因组基因座被转移到小鼠基因组中。实现这一目标的技术挑战很大，但已开始成功解决。
Mouse models have become an invaluable tool for understanding human health and disease owing to our ability to exquisitely manipulate the mouse genome. Recent progress in genomic analysis has led to an increase in the number and type of disease-causing mutations detected, and has also highlighted the importance of non-coding regions. As a result there is increasing interest in creating ‘genomically’ humanised mouse models, in which entire human genomic loci are transferred into the mouse genome. The technical challenges to achieving this aim are large but are starting to be tackled with success.