Effects of electroconvulsive therapy on neural complexity in patients with depression: Report of three cases
Effects of electroconvulsive therapy on neural complexity in patients with depression: Report of three cases
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DOI：
10.1016/j.jad.2013.04.029
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发表时间：
2013-09-05
影响因子：
6.6
通讯作者：
Wada, Yuji
中科院分区：
文献类型：
--
作者：
Okazaki, Ryoko;Takahashi, Tetsuya;Wada, Yuji
背景：电休克疗法（ECT）治疗抑郁症的确切神经生理机制仍然是一个谜。以往的神经生理学研究结果支持抑郁症的病理生理学基础是异常的功能连接，从而产生异常的脑电图（EEG）复杂性的假设。方法：最近发展的多尺度熵分析，支持异常的功能连接的精神障碍，探讨在ECT发生在3例抑郁症患者的EEG复杂性的变化。结果：所有患者均表现出EEG复杂性降低，尤其是在较高频率下。这种减少与抑郁症状的改善有关。Limitations：我们的研究结果的普遍性受到限制，因为老年人的小样本量和缺乏与健康controls.Conclusions的比较：ECT的EEG复杂性的降低可能是改善抑郁症患者大脑功能连接的结果。多尺度熵分析可能是阐明抑郁症的神经生理机制和评价ECT治疗效果的一种有用的分析方法。(C)2013 Elsevier B.V.保留所有权利。
Background: The exact neurophysiological mechanism of electroconvulsive therapy (ECT) for treating patients with depression remains elusive. Results of previous neurophysiological studies support the hypothesis that aberrant functional connectivity underlies the pathophysiology of depression, which engenders abnormal electroencephalogram (EEG) complexity.Methods: Recently developed multiscale entropy analysis, which has underpinned aberrant functional connectivity in mental disorders, was introduced to explore changes in EEG complexity occurring with ECT in three patients with depression.Results: All patients demonstrated a decrease in EEG complexity, especially at higher frequencies. This decrease was associated with improvement of depressive symptoms.Limitations: The generalizability of our findings was constrained because oldie small sample size and lack of a comparison with healthy controls.Conclusions: The decrease in EEG complexity with ECT might be a result of amelioration of functional connectivity in the brain of a depressed patient. Multiscale entropy analysis might be a useful analytical method to elucidate neurophysiological mechanisms and evaluate the therapeutic efficacy of ECT in depression. (C) 2013 Elsevier B.V. All rights reserved.