Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm.
Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm.
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外膜VASA血管的灌注不足会形成腹部主动脉瘤。
DOI：
10.1371/journal.pone.0134386
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Unno N
中科院分区：
文献类型：
--
作者：
Tanaka H;Zaima N;Sasaki T;Sano M;Yamamoto N;Saito T;Inuzuka K;Hayasaka T;Goto-Inoue N;Sugiura Y;Sato K;Kugo H;Moriyama T;Konno H;Setou M;Unno N
血管外血管（VV）灌注主动脉壁。组织缺氧是腹主动脉瘤（AAAs）肿大的表现之一。我们试图确定外来VV灌注不足是否会发展为AAAs。我们建立了一种新型的大鼠肾下腹主动脉外置聚氨酯导管与缝合结扎相结合的VV低灌注动物模型。VV低灌注引起组织缺氧，发展为肾下AAA，其形态和病理特征与人AAA相似。在人AAA组织中，小AAAs（直径30-49 mm）和大AAAs（直径100 - 50 mm）的外膜VV均狭窄，且其囊组织缺血和缺氧。这些结果表明，静脉外灌注不足对静脉下AAA的发展有重要影响。
The aortic wall is perfused by the adventitial vasa vasorum (VV). Tissue hypoxia has previously been observed as a manifestation of enlarged abdominal aortic aneurysms (AAAs). We sought to determine whether hypoperfusion of the adventitial VV could develop AAAs. We created a novel animal model of adventitial VV hypoperfusion with a combination of a polyurethane catheter insertion and a suture ligation of the infrarenal abdominal aorta in rats. VV hypoperfusion caused tissue hypoxia and developed infrarenal AAA, which had similar morphological and pathological characteristics to human AAA. In human AAA tissue, the adventitial VV were stenotic in both small AAAs (30–49 mm in diameter) and in large AAAs (> 50 mm in diameter), with the sac tissue in these AAAs being ischemic and hypoxic. These results indicate that hypoperfusion of adventitial VV has critical effects on the development of infrarenal AAA.