Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis.
Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis.
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DOI：
10.1037//0021-843x.104.2.286
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发表时间：
1995-05
影响因子：
4.6
通讯作者：
S. Faraone;L. Seidman;W. Kremen;J. Pepple;Melinda Lyons;M. Tsuang
中科院分区：
文献类型：
--
作者：
S. Faraone;L. Seidman;W. Kremen;J. Pepple;Melinda Lyons;M. Tsuang
许多研究表明，精神分裂症患者的亲属表现出的神经心理障碍较轻，但与精神分裂症患者相似。作者使用临床和实验性神经心理学成套测验对35名精神分裂症患者的非精神病亲属和72名正常对照进行了评估。三个神经心理功能符合精神分裂症基因型风险指标的标准：抽象，言语记忆和听觉注意力。这些发现不能归因于父母的社会经济地位，教育，一般的视觉空间能力，或精神病理学。此外，进行探索性分析，以确定是否可以调整指标的诊断效率，以满足遗传连锁分析的需要。这些分析表明，心理测量的考虑可能有助于创建遗传连锁研究的措施。
Numerous studies suggest that the relatives of schizophrenic patients exhibit neuropsychological impairments that are milder yet similar to those seen among schizophrenic patients. The authors assessed 35 nonpsychotic relatives of schizophrenic patients and 72 normal controls using a clinical and experimental neuropsychological test battery. Three neuropsychological functions met criteria for risk indicators of the schizophrenia genotype: abstraction, verbal memory, and auditory attention. These findings could not be attributed to parental socioeconomic status, education, general visual-spatial ability, or psychopathology. Furthermore, exploratory analyses were performed to determine whether the diagnostic efficiency of the indicators could be adjusted to meet the needs of genetic linkage analyses. These analyses suggest that psychometric considerations may help to create measures for genetic linkage studies.