Genomics and population biology of Cryptosporidium species.
Genomics and population biology of Cryptosporidium species.
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DOI：
10.1111/j.1365-3024.2011.01301.x
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发表时间：
2012-02
影响因子：
2.2
通讯作者：
Sullivan S
中科院分区：
文献类型：
--
作者：
Widmer G;Sullivan S
We describe recent advances in the genomics and population biology ofCryptosporidium parvumandC. hominis, the causative agents of cryptosporidiosis in humans and animals. Many basic aspects of the biology ofCryptosporidiumspecies remain to be investigated and effective drugs to control cryptosporidiosis are not available. Sequencing and annotation of the genome ofC. parvumandC. hominishas uncovered unique features of the metabolism of these species. The recently sequenced genome of the gastric speciesC. murisis providing new insights into the evolution of the genus. Cryptosporidian sequence information has facilitated the identification of polymorphic genetic markers. Genotyping of oocysts excreted by human and animal hosts using such markers has revealed many new species and genotypes, and is leading to a better understanding of the epidemiology of cryptosporidiosis.
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