Drug Delivery to the Brain: Recent Advances and Unmet Challenges.
Drug Delivery to the Brain: Recent Advances and Unmet Challenges.
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DOI：
10.3390/pharmaceutics15122658
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发表时间：
2023-11-23
期刊：
影响因子：
5.4
通讯作者：
Nair M
中科院分区：
文献类型：
--
作者：
Bhunia S;Kolishetti N;Vashist A;Yndart Arias A;Brooks D;Nair M
脑癌和神经退行性疾病正在上升，中枢神经系统（CNS）疾病的治疗仍然有限。尽管随着基因治疗或重组蛋白等新兴生物药物的出现，药物开发技术取得了显著进步，但此类生物药物治疗CNS疾病的临床转化率极低。血脑屏障（BBB）将脑与血液分离并保护CNS微环境以维持基本的神经元功能，这对CNS药物递送提出了最大的挑战。近年来，研究者们开发了多种药物转运策略，包括通过物理和化学方法局部破坏血脑屏障，以及靶向脑毛细血管表达的内源性蛋白质，通过胞吞作用转运药物穿过血脑屏障。药物递送至脑是一个不断发展的主题，尽管文献中有多篇综述文章，但由于该主题研究的持续增长和新的创新，有必要进行更新。因此，本次审查是一种尝试，以突出最近的策略，以克服CNS药物输送的挑战，同时强调投资更多的努力，在CNS药物输送技术平行于药物开发的必要性。
Brain cancers and neurodegenerative diseases are on the rise, treatments for central nervous system (CNS) diseases remain limited. Despite the significant advancement in drug development technology with emerging biopharmaceuticals like gene therapy or recombinant protein, the clinical translational rate of such biopharmaceuticals to treat CNS disease is extremely poor. The blood–brain barrier (BBB), which separates the brain from blood and protects the CNS microenvironment to maintain essential neuronal functions, poses the greatest challenge for CNS drug delivery. Many strategies have been developed over the years which include local disruption of BBB via physical and chemical methods, and drug transport across BBB via transcytosis by targeting some endogenous proteins expressed on brain-capillary. Drug delivery to brain is an ever-evolving topic, although there were multiple review articles in literature, an update is warranted due to continued growth and new innovations of research on this topic. Thus, this review is an attempt to highlight the recent strategies employed to overcome challenges of CNS drug delivery while emphasizing the necessity of investing more efforts in CNS drug delivery technologies parallel to drug development.
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影响因子：
10
作者：
Bhunia, Sukanya;Jaiswal, Manish K.;Singh, Kanwar Abhay;Deo, Kaivalya A.;Gaharwar, Akhilesh K.
通讯作者：
Gaharwar, Akhilesh K.
影响因子：
3
作者：
Astary, Garrett W.;Kantorovich, Svetlana;Carney, Paul R.;Mareci, Thomas H.;Sarntinoranont, Malisa
通讯作者：
Sarntinoranont, Malisa
DOI：
10.1073/pnas.2021915118
发表时间：
2021-05-04
影响因子：
11.1
作者：
Burks, Scott R.;Kersch, Cymon N.;Frank, Joseph A.
通讯作者：
Frank, Joseph A.
影响因子：
4.9
作者：
Bhunia, Sukanya;Vangala, Venugopal;Chaudhuri, Arabinda
通讯作者：
Chaudhuri, Arabinda
影响因子：
15.9
作者：
Alkins, Ryan;Burgess, Alison;Hynynen, Kullervo
通讯作者：
Hynynen, Kullervo