Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients.
Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients.
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DOI：
10.2174/1874210601408010136
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
M A I
中科院分区：
文献类型：
--
作者：
E I A;V J;D R H;A T S;A W S;K E;M A I
癌细胞表现出 DNA 及其表达的特征性损伤。肿瘤抑制因子 E-钙粘蛋白和 p27Kip1 的表达已在印度尼西亚受试者的 57 例头颈鳞状细胞癌 (HNSCC) 中进行了测试。根据公认的伦理要求，包括原发性和（不相关）淋巴结病例的 HNSCC 肿瘤样本是从印度尼西亚医院的档案中获得的。 E-钙粘蛋白或 p27Kip1 表达的降低与原发性和结节生长的恶性程度增加之间仅发现适度的相关性。无论是否恶性，观察到的 E-钙粘蛋白和 p27Kip1 表达水平之间的强相关性表明，将这些结合起来也无助于更好地预测 HNSCC 的结果。
Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27Kip1 has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27Kip1 with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC.