A modified international prognostic index including pretreatment hemoglobin level for early stage extranodal natural killer/T cell lymphoma
A modified international prognostic index including pretreatment hemoglobin level for early stage extranodal natural killer/T cell lymphoma
复制标题
改良的国际预后指数，包括早期结外自然杀伤/T细胞淋巴瘤的治疗前血红蛋白水平
DOI：
10.3109/10428194.2015.1026817
复制
发表时间：
2015-11-02
影响因子：
2.6
通讯作者：
Zhang, Yu-jing
中科院分区：
文献类型：
--
作者：
Wang, Liang;Xia, Zhong-jun;Zhang, Yu-jing
在这项研究中，我们研究了预处理血红蛋白水平在321例I/II期结外自然杀伤（NK/T细胞淋巴瘤（ENKTL））患者中的预后作用。预处理血红蛋白水平< 120 g/L的患者无进展生存期（PFS）和总生存期（OS）明显低于血红蛋白水平≥120 g/L的患者（p < 0.05）。在多因素Cox回归模型中，年龄、东部肿瘤合作组（工作状态）、乳酸脱氢酶水平、Ann Arbor分期、预处理血红蛋白水平均为PFS和OS的独立预后因素（p < 0.05）。利用这5个参数，构建了改进的国际预后指数（mIPI）模型。该mIPI可以在训练集和验证集中对PFS和OS有显著差异（p < 0.0001）的三组进行分类。综上所述，本研究证实了预处理血红蛋白水平在ENKTL中的预后作用，包含预处理血红蛋白水平的新改良IPI可用于进一步优化I/II期ENKTL患者的治疗，特别是在天冬酰胺酶时代。
In this study, we investigated the prognostic role of pretreatment hemoglobin level in 321 patients with stage I/II extranodal natural killer (NK/T cell lymphoma (ENKTL). Patients with pretreatment hemoglobin level < 120 g/L had significantly inferior progression-free survival (PFS) and overall survival (OS) than those with hemoglobin level ≥ 120 g/L (p < 0.05). In a multivariate Cox regression model, age, Eastern Cooperative Oncology Group (performance status), lactate dehydrogenase level, Ann Arbor stage and pretreatment hemoglobin level were all independent prognostic factors for PFS and OS (p < 0.05). Using these five parameters, a modified international prognostic index (mIPI) model was constructed. This mIPI could categorize three groups with significantly different PFS and OS (both p < 0.0001) in both the training set and the validation set. In conclusion, this study confirmed the prognostic role of pretreatment hemoglobin level in ENKTL, and a newly modified IPI including pretreatment hemoglobin level could be used to further optimize treatments for patients with stage I/II ENKTL, especially in the era of asparaginase.