Tumor deposits in head and neck carcinomas
Tumor deposits in head and neck carcinomas
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DOI：
10.1002/hed.23981
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发表时间：
2016-04-01
影响因子：
2.9
通讯作者：
Ikiz, Ahmet Omer
中科院分区：
文献类型：
--
作者：
Sarioglu, Sulen;Akbulut, Nilhan;Ikiz, Ahmet Omer
背景肿瘤沉积，肿瘤周围脂肪组织中的结节，没有淋巴结的结构残留，以前曾在结直肠腺癌中描述过。然而，到目前为止，还没有检查肿瘤沉积在头颈部鳞状细胞癌（HNSCC）。对140例HNSCC患者的颈清扫标本进行肿瘤沉积的再评价。24例（17%）检测到肿瘤沉积物。有肿瘤沉积的病例有更多的淋巴管浸润（p = .007），更高的病理N分类（p = .00），更频繁地显示远处转移（p = .003）。肿瘤存款阳性病例的无病生存期和总生存期显著较短（分别为p = 0.016和p = 0.005）。只有肿瘤沉积物对总生存率有意义。肿瘤沉积物使疾病复发的风险增加2294倍。肿瘤沉积物和囊周浸润被确定为独立的预后标志物;肿瘤沉积物增加疾病死亡风险3.4倍，而囊周浸润与死亡风险增加2.2倍相关。这些结果突出了颈淋巴结清扫标本中肿瘤沉积的存在及其与预后不良的关系。(C)2015 Wiley Periodicals，Inc.
Background. Tumor deposits, nodules in the peritumoral adipose tissue with no architectural residue of lymph node, have previously been described in colorectal adenocarcinomas. To date, however, there has been no examination of tumor deposits in head and neck squamous cell carcinoma (HNSCC).Methods. Neck dissection specimens of 140 patients with HNSCC were reevaluated for tumor deposits.Results. Tumor deposits were detected in 24 cases (17%). Cases with tumor deposits had more lymphatic invasion (p = .007), higher pathological N classification (p = .00), and more frequently showed distant metastasis (p = .003). Disease-free and overall survival were significantly shorter for tumor deposit positive cases (p = .016 and p = .005, respectively). Only tumor deposits were significant for overall survival. Tumor deposits increased the risk of recurrent disease 2294 times. Tumor deposits and pericapsular invasion were identified as independent prognostic markers; tumor deposits increased the risk of death from disease 3.4 times, whereas pericapsular invasion was associated with a 2.2-fold increase in the risk of death.Conclusion. These results highlight the existence of tumor deposits in neck dissection specimens of HNSCC and their association with poor prognosis. (C) 2015 Wiley Periodicals, Inc.