Self-reported quality of life across mood states in bipolar disorder.
Self-reported quality of life across mood states in bipolar disorder.
复制标题
双相情感障碍患者自我报告的不同情绪状态的生活质量。
作者：
C. Vojta;B. Kinosian;H. Glick;L. Altshuler;M. Bauer
与躁狂和轻躁狂的经典概念不同，越来越多的研究表明，这些发作的典型特征不是愉悦的情绪和幸福感的增加，而是明显的烦躁症状。然而，关于躁狂或轻躁狂的自我感知生活质量的数据很少。这些数据对于更好地了解这种疾病非常重要，对于开展适当的成本效用研究尤其重要。因此，我们假设两种自我报告生活质量的测量方法，即短表格12 （SF-12）的精神分量表和EuroQol，将显示躁狂/轻躁狂或混合发作患者的生活质量比那些心境平和的患者低。来自四个退伍军人事务部（VA）医疗中心的86名双相情感障碍患者采用横断面设计进行评估。心境状态分为医师诊断和患者自我报告两大类，分别采用内部状态量表（ISS）。使用SF-12和EuroQol对自我报告的生活质量进行量化。无论情绪状态如何决定，结果都是相同的。SF-12心理分量表和EuroQol在不同情绪状态下存在显著差异。躁狂/轻躁狂患者要么低于（SF-12精神亚量表），要么等于（EuroQol）心境正常的患者，而混合发作的患者在这两个指标上与抑郁发作的患者相似。相反，SF-12身体分量表得分没有组间差异。这些生活质量数据进一步支持这样一种概念，即躁狂和轻躁狂是以幸福感和生活质量降低而不是增加为特征的综合征。此外，抑郁症状似乎是双相情感障碍患者生活质量的主要决定因素，尽管其他因素可能与双相情感障碍患者的抑郁和生活质量下降有关。
In distinction to the classic conceptualization of mania and hypomania, a growing body of work indicates that these episodes are not typically characterized by euphoric mood and sense of increased well-being, but rather by significant dysphoric symptoms. However, few data exist concerning self-perceived quality of life in mania or hypomania. Such data are important both for better understanding of the illness, and are particularly important for developing appropriate cost-utility studies. Accordingly, we hypothesized that two measures of self-reported quality of life, the mental subscale of the Short Form-12 (SF-12) and the EuroQol, would show reduced quality of life in patients in manic/hypomanic or mixed episodes, compared to those who were euthymic. Eighty-six patients with bipolar disorder from four Department of Veterans Affairs (VA) medical centers were assessed in a cross-sectional design. Mood state was categorized by physician diagnosis and separately by patient self-report using the Internal State Scale (ISS). Self-reported quality of life was quantified using the SF-12 and EuroQol. Findings were identical regardless of how mood state was determined. The SF-12 mental subscale and EuroQol differed significantly across mood states. Patients with mania/hypomania were either less than (SF-12 mental subscale) or equal to (EuroQol) euthymic patients, while patients in a mixed episode resembled those in a depressive episode on both indices. In contrast, SF-12 physical subscale scores showed no intergroup differences. These quality-of-life data provide further support for the conceptualization that mania and hypomania are syndromes characterized by reduced, rather than increased, sense of well-being and quality of life. Moreover, depressive symptoms appear to be the primary determinant of quality of life in bipolar disorder, although other factors may be associated with both depression and reduced quality of life in bipolar disorder.
通过自我评分对躁狂和抑郁症状进行独立评估。
影响因子：
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作者：
Bauer,MS;Crits-Christoph,P;Ball,WA;Dewees,E;McAllister,T;Alahi,P;Cacciola,J;Whybrow,PC
通讯作者：
Whybrow,PC
影响因子：
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作者：
Harrow,M;Goldberg,JF;Grossman,LS;Meltzer,HY
通讯作者：
Meltzer,HY
影响因子：
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作者：
Tohen,M;Waternaux,CM;Tsuang,MT
通讯作者：
Tsuang,MT