Increased urinary C-type natriuretic peptide excretion may be an early marker of renal tubulointerstitial fibrosis
Increased urinary C-type natriuretic peptide excretion may be an early marker of renal tubulointerstitial fibrosis
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尿C型利钠肽排泄增加可能是肾小管间质纤维化的早期标志
DOI：
10.1016/j.peptides.2012.06.009
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发表时间：
2012-09-01
期刊：
影响因子：
3
通讯作者：
Qin, Yuan Han
中科院分区：
文献类型：
--
作者：
Hu, Peng;Wang, Jing;Qin, Yuan Han
尽管最近的重大进展使人们对其病理生理途径有了更好的了解，但小管间质纤维化（TIF）目前仍无法治愈。因此，早期发现可能意味着这种情况比过去更容易控制。c型利钠肽（CNP）已被发现是一种有效的血管舒张剂，但是一种弱的利钠因子。此外，CNP也被认为在小管细胞中产生，并作为具有抗炎和抗增殖作用的局部调节剂出现。CNP的消除主要有三种机制：中性内肽酶、利钠肽受体c和尿排泄。其中尿CNP排泄在肾病中的地位尚未完全阐明。本研究采用单侧输尿管梗阻（UUO）或假手术治疗大鼠亚组，观察24 h ~ 3个月。与假手术大鼠相比，结扎后24小时至1个月UUO大鼠尿CNP排泄明显增加。尿中CNP排泄量也明显高于腹主动脉和肾静脉的CNP浓度，这两种血管中CNP浓度几乎相同，排除了肾脏提取的系统性循环CNP。尿CNP排泄量与尿蛋白浓度、血尿素氮、肌酐呈负相关，与白蛋白呈正相关。总之，尿CNP排泄增加与TIF进展密切相关，可能是TIF的早期标志。(C) 2012爱思唯尔公司版权所有。
Although recent major advances have developed a much better understanding of the pathophysiological pathways, tubulointerstitial fibrosis (TIF) is still currently incurable. Therefore, early detection may mean that the condition is more manageable than it was in the past. C-type natriuretic peptide (CNP) has been found to be a potent vasodilator but a weak natriuretic factor. In addition, CNP has also been believed to be produced in tubular cells and presented as a local modulator with anti-inflammatory and anti-proliferative effects. Elimination of CNP occurs by three main mechanisms, neutral endopeptidase, natriuretic peptide receptor-C and urinary excretion. Among them, the status of urinary CNP excretion in nephropathies is not yet fully elucidated. In the present study, subgroups of rats were subjected to unilateral ureteral obstruction (UUO) or sham operation and observed for 24 h to 3 months. Urinary CNP excretion was significantly enhanced in UUO rats from 24h to 1 month post-ligation compared to sham-operated rats. Urinary CNP excretion was also markedly higher than CNP concentrations both in abdominal aorta and in renal vein, and almost identical concentrations in these two vessels excluded major renal extraction of circulating CNP of systemic origin. Urinary CNP excretion was negatively correlated with urinary protein concentration, blood urea nitrogen and creatinine, while positively correlated with albumin. In conclusion, the increased urinary CNP excretion is strongly associated with TIF progression, and may serve as an early marker of TIF. (C) 2012 Elsevier Inc. All rights reserved.