Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection
Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection
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DOI：
10.1016/j.clim.2009.03.001
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发表时间：
2009-07-01
影响因子：
8.6
通讯作者：
Wang, Fu-Sheng
中科院分区：
文献类型：
--
作者：
Shi, Ming;Fu, Junliang;Wang, Fu-Sheng
慢性B肝炎（CHB）患者的持续免疫转移在HBV的清除中起着重要作用。然而，目前尚不清楚，是否马槟榔诱导的杀伤（CIK）细胞可以抑制慢性乙型肝炎患者的HBV复制，特别是如果耐药性的发展。在这项研究中，功能性CIK细胞有效地从21例CHB患者中产生，并以自体方式输注。我们发现，慢性乙型肝炎患者的CIK细胞表现出大量的增殖和功能。给予CIK细胞与部分患者血清HBV含量下降和肝功能改善密切相关。基线血清丙氨酸氨基转移酶（ALT）水平>40 U/L的患者的病毒学应答率高于基线血清ALT水平40 U/L的患者。未观察到严重副作用。该方案代表了该疾病的替代免疫治疗策略。(C)2009年由Elsevier Inc.出版
Adoptive immune transfer plays an important rote in clearance of hepatitis B virus (HBV) in chronic hepatitis B (CHB) patients. However, it is unclear whether cytokine-induced killer (CIK) cells could suppress HBV replication in CHB patients, especially if drug resistance develops. In this study, functional CIK cells were efficiently generated from 21 CHB patients and were transfused in an autologous manner. We found that CIK cells from the CHB patients displayed substantial proliferation and function. Administration of the CIK cells closely correlated with the decrease in the serum HBV toad and improvement in liver function in some patients. The virological response rate in patients with baseline serum alanine aminotransferase (ALT) levels of >40 U/L was higher than that in patients with baseline serum ALT levels of 40 U/L. No serious side effects were observed. This protocol represents an alternative immune therapeutic strategy for the disease. (C) 2009 Published by Elsevier Inc.