Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents: A prospective clinical study
Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents: A prospective clinical study
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DOI：
10.1089/acm.2006.12.669
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发表时间：
2006-09-01
影响因子：
2.6
通讯作者：
Hara, Yukihiko
中科院分区：
文献类型：
--
作者：
Yamada, Hiroshi;Takuma, Norikata;Hara, Yukihiko
目的：目的：评价含漱茶儿茶素提取物对老年疗养院居民流感感染的预防作用。设计：前瞻性研究，从2005年1月至3月进行3个月。76名居民（83 +/- 8.2岁，平均值+/-标准差; 24名男性，52名女性）用茶儿茶素提取物（儿茶素组）漱口，并与48名年龄和性别匹配的居民进行比较，他们漱口时不使用茶儿茶素提取物（对照组）。干预措施：儿茶素组：用茶儿茶素提取液（200 μ g/mL儿茶素，60%的儿茶素中含有表没食子儿茶素没食子酸酯）漱口;对照组：不用儿茶素提取液漱口。两组患者均每日漱口3次，连续3个月。结果：比较两组患者在研究期间流感感染的发生率。结果：儿茶素组流感病毒感染发生率明显低于对照组（P < 0. 05（1.3%，1名居民）比对照组（10%，5名居民）通过多变量logistic回归分析计算（P = 0.028;比值比，15.711; 95%置信区间，1.883-399.658）。没有不良事件，如呼吸道刺激，阻塞，或过敏性支气管痉挛，观察在study.Conclusions：这项前瞻性研究表明儿茶素漱口对预防老年人流感感染的影响是首次在文献中报道。需要进一步的随机对照研究来证实儿茶素漱口对预防流感感染的作用。
Objectives: To evaluate the effects of gargling tea catechin extracts on the prevention of influenza infection in elderly nursing home residents.Design: A prospective study conducted for 3 months from January to March 2005.Settings/location: A nursing home in Japan.Subjects: A total of 124 elderly residents of at least 65 years of age were enrolled in the study. Seventy-six residents (83 +/- 8.2 years, mean +/- standard deviation; 24 men, 52 women) gargled with tea catechin extract (catechin group) and were compared with 48 age- and sex-matched residents who gargled without tea catechin extracts (control group). All the residents were vaccinated with an influenza vaccine until early December 2004.Interventions: catechin group: gargling with the tea catechin extract solution (200 mu g/mL catechins, 60% of catechins comprise epigallocatechin gallate); control group: gargling without the catechin extract solution. In both groups, gargling was performed three times daily for 3 months.Outcome measures: The incidence of influenza infection during the study was compared between the two groups. A safety evaluation was conducted to observe adverse events during the study.Results: The incidence of influenza infection was significantly lower in the catechin group (1.3%, one resident) than in the control group (10%, five residents) calculated by multivariate logistic regression analysis (P = 0.028; odds ratio, 15.711; 95% confidence interval, 1.883-399.658). No adverse events, such as respiratory tract irritation, an obstruction, or allergic bronchial spasm, were observed during the study.Conclusions: This prospective study demonstrating the effect of catechin gargling on the prevention of influenza infection in the elderly is the first to be reported in the literature. Further randomized, controlled studies are needed to confirm the effects of catechin gargling on the prevention of influenza infection.