Does high MHC class II gene expression in normal lungs account for the strong immunogenicity of lung allografts?
Does high MHC class II gene expression in normal lungs account for the strong immunogenicity of lung allografts?
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正常肺中 MHC II 类基因的高表达是否可以解释同种异体肺移植物的强免疫原性？
DOI：
10.1007/bf00335663
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Kittur,DS
中科院分区：
文献类型：
--
作者：
Alwayn,IP;Xu,R;Adler,WH;Kittur,DS
临床经验表明，肺移植物的免疫原性比肝移植物高得多，尽管两种器官含有等量的淋巴网状组织。用I-AB和I-EB基因特异性寡核苷酸探针对小鼠各种器官中的MHC II类基因表达进行北方印迹分析，结果表明，肺中的MHC II类基因表达半定量高于肝脏和除脾脏外的其他器官。我们的结论是，这种高MHC II类表达强烈表明，在肺淋巴网状组织处于激活状态。这可能是同种异体肺移植免疫原性强的重要原因。
Clinical experience has demonstrated that lung allografts are considerably more immunogenic than liver allografts although both organs contain equivalent amounts of lymphoreticular tissue. Northern blot analysis of MHC class II gene expression in various murine organs with I-AB and I-EB gene-specific oligonucleotide probes revealed that MHC class II expression in lungs is semiquantitatively higher than in the liver and other organs with the exception of the spleen. We conclude that this high MHC class II expression strongly suggests that the lymphoreticular tissue in the lungs is in a state of activation. This may be an important reason for the strong immunogenicity of lung allografts.