Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
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DOI：
10.1590/1414-431x20155003
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发表时间：
2016-03-01
影响因子：
2.3
通讯作者：
Ribeiro, M.O.
中科院分区：
文献类型：
--
作者：
Bocco, B.M.;Fernandes, G.W.;Ribeiro, M.O.
对钩丝酵母（Baccharis uncinella C.）DC.（菊科）导致咖啡酸和阿魏酸的分离，这是从光谱和光谱证据。这些化合物表现出抗氧化和抗炎特性，并已被证明在预防/治疗代谢综合征中有效。这项研究调查了咖啡酸和阿魏酸的联合治疗是否在代谢综合征小鼠模型中表现出更显着的有益效果。咖啡酸和阿魏酸的组合治疗在保持高脂肪（40%）饮食的C57小鼠中测试60天。所获得的数据表明，用咖啡酸和阿魏酸处理防止了由高脂肪饮食诱导的体重增加，并改善了高血糖症、高胆固醇血症和高胆固醇血症。在这些动物的肝脏中，许多代谢相关基因的表达受到影响，表明咖啡酸和阿魏酸处理导致肝脏中胆固醇摄取增加和肝脏甘油三酯合成减少，这是预防肝脂肪变性的可能解释。总之，咖啡酸和阿魏酸的组合治疗在肥胖小鼠模型中对预防代谢综合征和肝脏脂肪变性的多个方面显示出主要的积极作用。
Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.