Comparing adult hippocampal neurogenesis in mammalian species and orders: influence of chronological age and life history stage
Comparing adult hippocampal neurogenesis in mammalian species and orders: influence of chronological age and life history stage
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DOI：
10.1111/j.1460-9568.2011.07804.x
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发表时间：
2011-09-01
影响因子：
3.4
通讯作者：
Lipp, Hans-Peter
中科院分区：
文献类型：
--
作者：
Amrein, Irmgard;Isler, Karin;Lipp, Hans-Peter
成年海马神经发生是啮齿类动物的一个突出事件。在预期寿命较长的物种中，海马结构的成年齿状回中的新生细胞数量较少或可能完全不存在。多项证据表明，短命哺乳动物和长寿哺乳动物的成年神经发生的调节机制不同。在对与比较不同物种相关的因素和问题进行严格评估后，我们对七种实验室品系小鼠（BALB、C57BL/6、CD1、远交）和大鼠（F344、Sprague-Dawley、Wistar）、其他六种啮齿动物（其中四种是野生源的）（木鼠、田鼠、刺鼠和豚鼠）、三种非人类灵长类动物（狨猴和两种猕猴）和一种的进行了定量比较。肉食动物（红狐）。将增殖细胞的数量标准化为颗粒细胞总数，我们观察到增殖的整体指数下降，这种下降在时间上在物种和目之间是相等的，并且与早期发育过程和寿命无关。长寿和短命的哺乳动物在主要生命史阶段方面有所不同；在断奶、首次繁殖年龄和平均预期寿命等时间点，长寿的灵长类动物和狐狸的增殖细胞明显少于啮齿类动物。尽管神经元分化的数据库有限，但我们发现有迹象表明神经元分化的程度受到物种特异性选择性适应的影响。我们得出的结论是，绝对年龄是调节哺乳动物成年海马细胞发生的关键因素。个体发生和生态因素主要影响神经元分化的调节，而不是细胞增殖的速率。
Adult hippocampal neurogenesis is a prominent event in rodents. In species with longer life expectancies, newly born cells in the adult dentate gyrus of the hippocampal formation are less abundant or can be completely absent. Several lines of evidence indicate that the regulatory mechanisms of adult neurogenesis differ between short-and long-lived mammals. After a critical appraisal of the factors and problems associated with comparing different species, we provide a quantitative comparison derived from seven laboratory strains of mice (BALB, C57BL/6, CD1, outbred) and rats (F344, Sprague-Dawley, Wistar), six other rodent species of which four are wild-derived (wood mouse, vole, spiny mouse and guinea pig), three non-human primate species (marmoset and two macaque species) and one carnivore (red fox). Normalizing the number of proliferating cells to total granule cell number, we observe an overall exponential decline in proliferation that is chronologically equal between species and orders and independent of early developmental processes and life span. Long- and short-lived mammals differ with regard to major life history stages; at the time points of weaning, age at first reproduction and average life expectancy, long-lived primates and foxes have significantly fewer proliferating cells than rodents. Although the database for neuronal differentiation is limited, we find indications that the extent of neuronal differentiation is subject to species-specific selective adaptations. We conclude that absolute age is the critical factor regulating cell genesis in the adult hippocampus of mammals. Ontogenetic and ecological factors primarily influence the regulation of neuronal differentiation rather than the rate of cell proliferation.