IMMOBILIZATION STRESS INDUCES INTERLEUKIN-1-BETA MESSENGER-RNA IN THE RAT HYPOTHALAMUS
IMMOBILIZATION STRESS INDUCES INTERLEUKIN-1-BETA MESSENGER-RNA IN THE RAT HYPOTHALAMUS
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DOI：
10.1016/0304-3940(91)90944-o
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发表时间：
1991-02-25
影响因子：
2.5
通讯作者：
SATOH, M
中科院分区：
文献类型：
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作者：
MINAMI, M;KURAISHI, Y;SATOH, M
固定应激诱导大鼠下丘脑中白细胞介素 1 β (IL-1 β) mRNA 的表达。 IL-1-β mRNA在固定开始后30分钟被诱导，在60分钟时达到最大值，然后在120分钟时仍检测到水平下降。 然而，固定开始240分钟后，尽管继续固定，但IL-1-β mRNA变得几乎检测不到。 固定开始后 30 和 60 分钟检查的任何其他脑区域均未检测到 IL-1-β mRNA 的明显表达。 这些结果表明，固定应激仅在下丘脑中诱导 IL-1-β mRNA 的表达，并表明 IL-1-β 参与了该处对应激的反应。
Immobilization stress induced interleukin-1-beta (IL-1-beta) mRNA in the rat hypothalamus. IL-1-beta mRNA was induced at 30 min after the start of immobilization, reached a maximum at 60 min and then was still detected with a decreased level at 120 min. However, 240 min after the start of the immobilization, IL-1-beta mRNA became hardly detectable despite the continuance of immobilization. Distinct expression of IL-1-beta mRNA was not detected in any other brain region examined at 30 and 60 min after the start of immobilization. These results demonstrate that the immobilization stress induces the expression of IL-1-beta mRNA solely in the hypothalamus and suggest that IL-1-beta is involved in the response to stress there.