DNA double-strand break repair and chromosome translocations
DNA double-strand break repair and chromosome translocations
复制标题
DOI：
10.1016/j.dnarep.2006.05.029
复制
发表时间：
2006-09-08
期刊：
影响因子：
3.8
通讯作者：
Kanaar, Roland
中科院分区：
文献类型：
--
作者：
Agarwal, Sheba;Tafel, Agnieszka A.;Kanaar, Roland
易位是指当一段断裂的染色体错误地重新连接到另一条染色体上时发生的遗传异常。易位产生的最初事件是DNA双链断裂(DSB)的形成，这既可以在生理情况下诱导，如在免疫系统的发育过程中，也可以由外源DNA损伤剂诱导。当DSB出现时，细胞中存在两条主要的修复途径，即同源重组和非同源末端连接。在某些情况下，这些途径可能会不适当地发挥作用，并错误地重新连接末端，从而产生基因组重排，包括易位。易位被认为与癌症有关，因为它们具有激活癌基因的能力。由于在DNA、细胞和组织水平上的选择，某些形式的癌症与特定的易位有关，可用作这些癌症的诊断和预后的工具。(C)2006爱思唯尔B.V.保留所有权利。
Translocations are genetic aberrations that occur when a broken fragment of a chromosome is erroneously rejoined to another chromosome. The initial event in the creation of a translocation is the formation of a DNA double-strand break (DSB), which can be induced both under physiological situations, such as during the development of the immune system, or by exogenous DNA damaging agents. Two major repair pathways exist in cells that repair DSBs as they arise, namely homologous recombination, and non homologous end-joining. In some situations these pathways can function inappropriately and rejoin ends incorrectly to produce genomic rearrangements, including translocations. Translocations have been implicated in cancer because of their ability to activate oncogenes. Due to selection at the level of the DNA, the cell, and the tissue certain forms of cancer are associated with specific translocations that can be used as a tool for diagnosis and prognosis of these cancers. (c) 2006 Elsevier B.V. All rights reserved.