THE EFFECTS OF DIETARY CALORIC RESTRICTION ON MATURITY AND SENESCENCE, WITH PARTICULAR REFERENCE TO FERTILITY AND LONGEVITY
THE EFFECTS OF DIETARY CALORIC RESTRICTION ON MATURITY AND SENESCENCE, WITH PARTICULAR REFERENCE TO FERTILITY AND LONGEVITY
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DOI：
10.1152/ajplegacy.1947.150.3.511
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发表时间：
1947-01-01
影响因子：
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通讯作者：
VISSCHER, MB
中科院分区：
文献类型：
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作者：
BALL, ZB;BARNES, RH;VISSCHER, MB
在8个月期间，A品系的卡路里喂养不足[雌性]小鼠的生育指数为0.08窝/小鼠/月。0.04岁以后当以前吃不饱的[女性] [女性]允许在8个月随意进食。在10岁时，它们的生育指数上升到0.65窝/小鼠/月，这接近于年轻全喂[雌性] [雌性]的正常水平。它的结论是，生殖能力方面的成熟被推迟或推迟低热量喂养时，通过大部分的平均体重。正常寿命热量喂养不足并没有阻止随后的成熟和正常妊娠，在这个年龄，全喂养的同窝姐妹篇从衰老变得几乎不育，生育指数仅为0.05窝/小鼠/月。在expts。据报道，25%的A品系9小鼠受到终身热量限制时，他们的全喂养的同窝姐妹篇已经死亡的年龄活着。考虑到在这些实验中超过240天的存活率，终身限制热量组的50%死亡时间，8个月。限饲组和全饲对照组分别为200、140和125天。讨论了影响这些观察结果的一些因素。这些研究中采用的热量限制延缓了性成熟，但并没有阻止其在随后的充分喂养时发生，并且与寿命延长的趋势有关。热量限制240天，随后的全喂养，并没有防止乳腺癌的显着发病率，虽然它增加了平均体重。癌症年龄高于可比的非处女，充分喂养的对照。
Calorie underfed [female] mice of the A strain show a fertility index of 0.08 litter/ mouse/month during the period to 8 mos. of age, and 0.04 thereafter. When previously underfed [female] [female] are allowed food ad libitum at 8 mos. of age, their fertility index rises to 0.65 litter /mouse/month, which approximates the normal for young full-fed [female] [female]. It is concluded that maturation with respect to reproductive capacity is retarded or postponed when low calorie feeding is imposed through a large fraction of the avg. normal life-span. The calorie underfeeding did not prevent subsequent maturation and normal gestation at an age when full-fed littermate sisters had become nearly sterile from senility, showing a fertility index of only 0,05 litter/mouse/mo. In the expts. reported, 25% of A strain 9 mice subjected to life-time caloric restriction were alive at an age when all of their full-fed littermate sisters had died. Considering the survival beyond 240 days in these expts., the 50% mortality times for the life-time calorie-restricted group, the 8 mo. restricted, subsequently full-fed group, and the full-fed controls were 200, 140 and 125 days, respectively. Some factors influencing the significance of these observations were discussed. The caloric restriction employed in these studies retarded sexual maturation but did not prevent its occurrence upon subsequent full-feeding, and was associated with a tendency toward a longer life-span. Caloric restriction for 240 days, with subsequent full-feeding, did not prevent a significant incidence of mammary carcinoma although it increased the avg. cancer age above that in comparable non-virgin, fully fed controls.