A Natural Animal Model System of Craniofacial Anomalies: The Blind Mexican Cavefish.
A Natural Animal Model System of Craniofacial Anomalies: The Blind Mexican Cavefish.
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DOI：
10.1002/ar.23998
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Powers AK
中科院分区：
文献类型：
--
作者：
Gross JB;Powers AK
在极端环境压力下进化的自然模型系统提供了机会来推进我们对颅面复合体如何在自然界中进化的认识。与传统模型不同，自然系统的近亲繁殖较少，因此可以更好地模拟人口的复杂变化。由于失明墨西哥洞穴鱼的某些颅面畸变的性质，我们认为这种生物可以为各种颅面变化提供新的见解。自然穴居的阿斯提亚克斯鱼已经进化出了多种颅骨特征，它们在洞穴中无情的黑暗和营养贫乏的环境中繁衍了无数代。虽然各种颅骨异常的遗传和环境基础已经研究了几十年，但对其分子和发育起源的全面表征仍然不完整。考虑到基因组资源、发育和分子工具的可用性，以及存在一个规范的地表生活“祖先”替代物，洞穴鱼提供了许多优势。通过利用异常和不对称的颅骨特征在洞穴鱼的频率，我们预计在我们的知识的进步不规则颅骨特征的病因。洞穴鱼的极端适应性有望为颅面疾病和面部不对称的复杂性和多因素性质提供新的见解。
Natural model systems evolving under extreme environmental pressures provide the opportunity to advance our knowledge of how the craniofacial complex evolves in nature. Unlike traditional models, natural systems are less inbred, and, therefore, better model the complex variation of the human population. Owing to the nature of certain craniofacial aberrations in blind Mexican cavefish, we suggest that this organism can provide new insights to a variety of craniofacial changes. Diverse cranial features have evolved in natural cave-dwelling Astyanax fish, which have thrived in the unforgiving darkness and nutrient-poor environment of the cave for countless generations. While the genetic and environmental underpinnings of various cranial anomalies have been investigated for decades, a comprehensive characterization of their molecular and developmental origins remains incomplete. Cavefish provide numerous advantages given the availability of genomic resources, developmental and molecular tools, and the presence of a normative surface-dwelling “ancestral” surrogate for comparative studies. By leveraging the frequency of abnormal and asymmetric cranial features in cavefish, we anticipate advances in our knowledge of the etiologies of irregular cranial features. Extreme adaptations in cavefish are expected to offer new insights into the complex and multifactorial nature of craniofacial disorders and facial asymmetry.
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影响因子：
3.3
作者：
Gross, Joshua B.;Krutzler, Amanda J.;Carlson, Brian M.
通讯作者：
Carlson, Brian M.
影响因子：
2.9
作者：
Gross JB;Stahl BA;Powers AK;Carlson BM
通讯作者：
Carlson BM
影响因子：
3.7
作者：
Hinaux H;Poulain J;Da Silva C;Noirot C;Jeffery WR;Casane D;Rétaux S
通讯作者：
Rétaux S
影响因子：
2
作者：
Hinaux, Helene;Pottin, Karen;Retaux, Sylvie
通讯作者：
Retaux, Sylvie
DOI：
10.1016/b978-0-12-802148-4.00010-4
发表时间：
2016-01-01
期刊：
BIOLOGY AND EVOLUTION OF THE MEXICAN CAVEFISH
影响因子：
--
作者：
Gross, Joshua B.;Powers, Amanda K.
通讯作者：
Powers, Amanda K.