Development of a novel FePt-based multifunctional ferroptosis agent for high-efficiency anticancer therapy
Development of a novel FePt-based multifunctional ferroptosis agent for high-efficiency anticancer therapy
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开发一种新型基于 FePt 的多功能铁死亡剂，用于高效抗癌治疗
DOI：
10.1039/c8nr05150j
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发表时间：
2018
期刊：
影响因子：
6.7
通讯作者：
Zheng Xiuwen
中科院分区：
文献类型：
--
作者：
Yue Ludan;Dai Zhichao;Chen Xu;Liu Chunmiao;Hu Zunfu;Song Bo;Zheng Xiuwen
铁凋亡作为一种新兴的肿瘤细胞杀伤机制已成为研究热点。本工作利用FePt纳米粒子中的稀土发光配合物PTTA-Eu ~（3+）和叶酸（FA），合理设计了一种新型的铁凋亡剂FePt-PTTA-Eu ~（3+）-FA（FPEF）。基于FePt的纳米材料在临床诊断中的磁共振成像/计算机断层扫描（MRI/CT）中具有潜在的应用，并且具有优异的诱导癌细胞死亡的能力。FPEP的机制研究表明，FePt诱导的癌细胞死亡被确认为铁凋亡机制。据我们所知，这将是第一份证明FePt纳米颗粒中存在铁沉淀过程的报告。FPEF的体外实验表明，所制备的纳米粒对FA阳性肿瘤细胞包括4 T1、MCF-7和HeLa细胞表现出令人满意的抗癌效果。使用荷瘤balb/c小鼠的体内研究显示，FPEF纳米颗粒可以显著抑制肿瘤进展。这种一体化的治疗策略在癌症的早期诊断、预后和治疗方面具有巨大的潜力。
Ferroptosis as an emerging mechanism has become a research hotspot for killing cancer cells. In this work, a novel ferroptosis agent, FePt-PTTA-Eu3+-FA (FPEF), was rationally designed by harnessing the luminescent lanthanide complexes PTTA-Eu3+ and folic acid (FA) in FePt nanoparticles. FePt-Based nanomaterials have potential applications in magnetic resonance imaging/computed tomography (MRI/CT) in clinical diagnosis and have excellent capacity to induce cancer cell death. Mechanistic studies of FPEP showed that the FePt induced cancer cell death was affirmed as the ferroptosis mechanism. To the best of our knowledge, it will be the first report that proves the existence of the ferroptosis process in FePt NPs. The in vitro tests of FPEF demonstrated that the as-prepared NPs exhibit a satisfactory anticancer effect towards FA-positive tumor cells including 4T1, MCF-7 and HeLa cells. The in vivo studies using tumor-bearing balb/c mice revealed that the FPEF NPs could significantly inhibit tumor progression. Such all-in-one therapeutic strategies have great potential in early diagnosis, prognosis and treatment of cancer.