Exercise capacity and cardiovascular/metabolic characteristics of overweight and obese individuals with type 2 diabetes - The look AHEAD clinical trial
Exercise capacity and cardiovascular/metabolic characteristics of overweight and obese individuals with type 2 diabetes - The look AHEAD clinical trial
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超重和肥胖 2 型糖尿病患者的运动能力和心血管/代谢特征 - Look AHEAD 临床试验
DOI：
10.2337/dc06-2487
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发表时间：
2007-10-01
期刊：
影响因子：
16.2
通讯作者：
Soberman, Judith E.
中科院分区：
文献类型：
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作者：
Ribisl, Paul M.;Lang, Wei;Soberman, Judith E.
我们使用来自 5,145 名超重和/或肥胖（BMI >= 25.0 kg/m(2)）男性和女性 2 型糖尿病患者的基线数据，研究了心血管、代谢和身体成分指标与运动能力之间的关联，这些患者是 Look AHEAD（糖尿病健康行动）临床试验的随机参与者。 研究设计和方法 - 在分级运动测试期间测量以 MET 表示的峰值运动能力，并根据跑步机速度和等级进行估计。 2 旨在激发最大努力。其他指标包括腰围、BMI、糖尿病类型持续时间、所用药物类型、A1C、心血管疾病史、代谢综合征、P-阻滞剂使用情况和种族/民族。 结果 - 男性的峰值运动能力 (8.0 +/- 2.1 MET) 高于女性 (6.7 +/- 1.7 MET) (P < 0.001)。两性的运动能力随着每十岁年龄的增长而下降（P < 0.001），并且随着 BMI 和腰围水平的增加而下降。年龄较大、腰围和体重指数增加、糖尿病病程较长、糖化血红蛋白升高、有心血管疾病史、患有代谢综合征、使用 P 阻滞剂、以及与白人相比，非洲裔美国人与男女峰值运动能力较低有关。高血压和糖尿病药物的使用与女性峰值运动能力较低有关。 结论 - 超重或肥胖的糖尿病患者运动能力受损，这主要与年龄、女性和种族以及代谢控制不良、BMI 和中心性肥胖有关。
We examined associations of cardiovascular, metabolic, and body composition measures with exercise capacity using baseline data from 5,145 over-weight and/or obese (BMI >= 25.0 kg/m(2)) men and women with type 2 diabetes who were randomized participants for the Look AHEAD (Action for Health in Diabetes) clinical trial.RESEARCH DESIGN AND METHODS - Peak exercise capacity expressed as METs and estimated from treadmill speed and grade was measured during a graded exercise test 2 designed to elicit a maximal effort. Other measures included waist circumference, BMI, type diabetes duration, types of medication used, A1C, history of cardiovascular disease, metabolic syndrome, P-blocker use, and race/ethnicity.RESULTS - Peak exercise capacity was higher for men (8.0 +/- 2.1 METs) than for women (6.7 +/- 1.7 METs) (P < 0.001). Exercise capacity also decreased across each decade of age (P < 0.001) and with increasing BMI and waist circumference levels in both sexes. Older age, increased waist circumference and BMI, a longer duration of diabetes, increased A1C, a history of cardiovascular disease, having metabolic syndrome, P-blocker use, and being African American compared with being Caucasian were associated with a lower peak exercise capacity for both sexes. Hypertension and use of diabetes medications were associated with lower peak exercise capacity in women.CONCLUSIONS - Individuals with diabetes who are overweight or obese have impaired exercise capacity, which is primarily related to age, female sex, and race, as well as poor metabolic control, BMI, and central obesity.