Obstructive sleep apnoea and urine catecholamines in hypertensive males: a population-based study
Obstructive sleep apnoea and urine catecholamines in hypertensive males: a population-based study
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DOI：
10.1183/09031936.02.00106402
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发表时间：
2002-03-01
影响因子：
24.3
通讯作者：
Boman, G
中科院分区：
文献类型：
--
作者：
Elmasry, A;Lindberg, E;Boman, G
针对阻塞性睡眠呼吸暂停（OSA）和交感肾上腺活动之间关系的研究受到批评，因为对已知混淆交感神经功能的因素（包括高血压）控制不佳。本研究的目的是调查阻塞性睡眠呼吸暂停与尿中儿茶酚胺的关系，在1994年，2,668名40-79岁的男性回答了关于睡眠障碍和躯体疾病的问卷。在那些报告高血压的人中，选择116名年龄分层样本进行睡眠呼吸监测和夜间尿液分析。OSA受试者定义为呼吸暂停低通气指数大于或等于10（.）h（-1），有较高浓度的尿normetaneetine（182 +/- 57 vs. 141 +/- 45 mumol（.）mol（-1）肌酐，p
Studies addressing the relationship between obstructive sleep apnoea (OSA) and sympathoadrenal activity have been criticized for poor control of factors known to confound sympathetic function, including hypertension. The aim of this study was to investigate the relationship between OSA and urinary catecholamines, in a population-based sample of hypertensive mates.In 1994, 2,668 males aged 40-79 yrs answered a questionnaire regarding sleep disorders and somatic diseases. Of those who reported hypertension, an age-stratified sample of 116 was selected for monitoring of breathing during sleep and overnight urine analysis.Subjects with OSA, defined as apnoea-hypopnoea index greater than or equal to 10(.)h(-1), had higher concentrations of urinary normetanephrine (182 +/- 57 versus 141 +/- 45 mumol(.)mol(-1) creatinine, p