Idiopathic chronic eosinophilic pneumonia.
Idiopathic chronic eosinophilic pneumonia.
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DOI：
10.1186/1750-1172-1-11
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发表时间：
2006-04-06
影响因子：
3.7
通讯作者：
Cordier JF
中科院分区：
文献类型：
--
作者：
Marchand E;Cordier JF
特发性慢性嗜酸性粒细胞肺炎(ICEP)是以亚急性或慢性呼吸道和全身症状、肺泡和/或血嗜酸粒细胞增多，以及胸部影像上周围肺的浸润性病变为特征的疾病。嗜酸性粒细胞增多症在大多数情况下都存在，通常超过1000个/mm3。在没有明显的血嗜酸性粒细胞增多症的情况下，ICEP的诊断被证实为支气管肺泡灌洗液嗜酸性粒细胞增多症。ICEP通常与支气管肺泡灌洗液中嗜酸性粒细胞计数高于淋巴细胞计数有关。ICEP是一种原因不明的罕见疾病。它的确切流行情况尚不清楚。ICEP可能会影响每个年龄段，但在儿童时期很少见。这种情况在女性中的发生率是男性的两倍。三分之一到一半的ICEP患者有哮喘史。ICEP的主要治疗方法是全身糖皮质激素。口服皮质类固醇治疗的反应是显著的，并已导致考虑将皮质类固醇激发作为ICEP的诊断试验。然而，当逐渐减少或停止治疗时，严重哮喘的复发或发展是频繁的。多达一半的患者需要长期口服皮质类固醇治疗。
Idiopathic chronic eosinophilic pneumonia (ICEP) is characterized by subacute or chronic respiratory and general symptoms, alveolar and/or blood eosinophilia, and peripheral pulmonary infiltrates on chest imaging. Eosinophilia is present in most cases, usually in excess of 1000/mm3. In absence of significant blood eosinophilia, a diagnosis of ICEP is supported by the demonstration of bronchoalveolar lavage eosinophilia. ICEP is typically associated with eosinophil counts higher than lymphocyte counts in the bronchoalveolar lavage. ICEP is a rare disorder of unknown cause. Its exact prevalence remains unknown. ICEP may affect every age group but is rare in childhood. It is twice as frequent in women as in men. One third to one half of the ICEP patients have a history of asthma. The mainstay of treatment of ICEP is systemic corticosteroids. Response to oral corticosteroid therapy is dramatic and has led to the consideration of corticosteroid challenge as a diagnostic test for ICEP. Nevertheless, relapses or development of severe asthma are frequent when tapering or withdrawing treatment. Long-term oral corticosteroid therapy is necessary in up to half of the patients.
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影响因子：
10
作者：
FOX, B;SEED, WA
通讯作者：
SEED, WA
影响因子：
24.3
作者：
Cottin, V;Frognier, R;Cordier, JF
通讯作者：
Cordier, JF
影响因子：
158.5
作者：
CARRINGT.CB;ADDINGTO.WW;GAENSLER, EA
通讯作者：
GAENSLER, EA
影响因子：
1.6
作者：
Guillevin, L;Cohen, P;Casassus, P
通讯作者：
Casassus, P
影响因子：
24.3
作者：
Marchand, E;Etienne-Mastroianni, B;Cordier, JF
通讯作者：
Cordier, JF