Ferrite-Coated Nanoparticles: Synthesis and Biomedical Applications
Ferrite-Coated Nanoparticles: Synthesis and Biomedical Applications
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铁氧体涂层纳米粒子：合成和生物医学应用
DOI：
10.3379/jmsjmag.22.s1_429
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发表时间：
1998
影响因子：
--
通讯作者：
B. Bar
中科院分区：
文献类型：
--
作者：
S. Margel;I. Burdygin;S. Gura;H. Bamnolker;B. Nitzan;M. Kedem;O. Melamed;Merav Zuberi;L. Boguslavsky;E. Mandel;L. Sheihet;T. Tennenbaum;B. Bar
-我们实验室最近制备并表征了新型实心和空心单分散微米级有机-无机杂化磁性纳米颗粒。通过铁盐在聚苯乙烯单分散微米尺寸(1-6J.1D)颗粒上的种子聚合形成固体颗粒。通过这些颗粒与Si(OEt) 4 的种子聚合来制备这些铁氧体涂覆颗粒的进一步涂层，其具有显着较小直径(30-40 nm)的二氧化硅纳米颗粒。证明了聚苯乙烯表面组成对聚苯乙烯与铁氧体和二氧化硅的结合的影响。空心铁氧体二氧化硅微米级颗粒是通过烧掉以前混合颗粒的聚苯乙烯核而形成的。这些颗粒的表面改性是通过使这些二氧化硅涂覆的颗粒与多种间醇试剂或间烷基硅烷化合物反应来进行的。还论证和讨论了这些铁氧体涂层颗粒的潜在生物医学用途。
-New solid and hollow monodispersed micron-sized organic-inorganic hybrid magnetic nan';lparticles have been recently prepared and characterized in our laboratory. The solid particles were formed by seeded polymerization of iron salts onto polystyrene monodispersed micron-sized (1-6 J.lID) particles. A further coating of these ferrite-coated particles with silica nanoparticles of significantly lower diameter (30-40 nm) was prepared by seeded polymerization of these particles with Si(OEt)4. The effect of the polystyrene surface composition on the ~ting of the polystyrene with ferrite and with silica is demonstrated. Hollow ferrite silica micron-sized particles were formed by burning off the polystyrene core of the former hybrid particles. Surface modification of these particles was performed by reacting these silica-coated particles with a variety of m-alcoholic reagents or m-alkylsilane compoWlds. The potential biomedical use of these ferrite-coated particles is also demonstrated and discussed.