Inhibition of myopia development in chicks using himbacine:: a role for M4 receptors?
Inhibition of myopia development in chicks using himbacine:: a role for M4 receptors?
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DOI：
10.1097/00001756-200108080-00033
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发表时间：
2001-08-08
期刊：
影响因子：
1.7
通讯作者：
McBrien, NA
中科院分区：
文献类型：
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作者：
Cottriall, CL;Truong, HT;McBrien, NA
M-1选择性毒蕈碱拮抗剂哌仑西平在动物模型中预防近视发展的成功暗示了M-1受体的作用。然而，所需的哌仑西平的相对高剂量可能表明药物通过另一种受体亚型起作用。这项研究检查了M-4选择性拮抗剂himbacine是否也可以预防近视。每天玻璃体内注射欣巴辛以剂量依赖的方式抑制鸡眼近视的诱导。与对照组相比，小于或等于200 μ g的剂量对诱发性近视没有显著抑制作用（-13.7 +/-2.3 vs -16.2 +/-0.9D，ANOVA p=0.37），而800 μ g的剂量几乎完全抑制了诱发性近视（-2.4 +/-2.0，p
The success of the M-1-selective muscarinic antagonist pirenzepine in preventing myopia development in animal models implicates a role for the M-1 receptor. However, the relatively high dose of pirenzepine required may indicate that the drug acts through another receptor subtype. This study examined whether the M-4-selective antagonist, himbacine, could also prevent myopia. Daily intravitreal injections of himbacine inhibited the inducement of myopia in chick eyes in a dose-dependent manner. Doses less than or equal to 200 mug caused no significant inhibition of induced myopia compared to controls (-13.7 +/-2.3 vs -16.2 +/-0.9D, ANOVA p=0.37), whilst a dose of 800 mug almost completely inhibited the induced myopia(-2.4 +/-2.0, p